美沙拉嗪联合双歧杆菌四联活菌片对溃疡性结肠炎患者炎性因子水平的影响

Effect of mesalazine combined with viable bifidobacterium quadruple tablets on inflammatory factors in patients with ulcerative colitis

目的探讨溃疡性结肠炎患者采用美沙拉嗪联合双歧杆菌四联活菌片对其炎性因子水平的影响。方法选取2016年3月—2018年6月商丘市长征人民医院溃疡性结肠炎患者80例,采用随机数表法分为参照组和实验组,每组40例。参照组采用美沙拉嗪治疗,实验组予美沙拉嗪联合双歧杆菌四联活菌片治疗,对比两组炎性因子水平。结果实验组治疗后白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)水平均低于参照组,IL-4水平较参照组高,差异有统计学意义(P<0.05)。结论溃疡性结肠炎患者采用美沙拉嗪联合双歧杆菌四联活菌片治疗效果显著,可有效调节炎症因子水平,改善患者病情。

Objective To investigate the effect of mesalazine combined with viable bifidobacterium quadruple tablets on inflammatory factors in patients with ulcerative colitis(UC).Methods Totally 80 UC patients in the hospital from March 2016 to June 2018 were divided into reference group and experimental group by random number table,with 40 cases in each group.Reference group was given mesalazine,while experimental group was treated with mesalazine combined with viable bifidobacterium quadruple tablets.The levels of inflammatory factors were compared between the two groups.Results After treatment,the levels of interleukin-8(IL-8)and high-sensitivity C-reactive protein(hs-CRP)in experimental group were lower than those in reference group,while the IL-4 level of experimental group was higher than that of the reference group(P<0.05).Conclusion Mesalazine combined with viable bifidobacterium quadruple tablets in treatment of UC is effective,it can regulate the levels of inflammatory factors and improve patients’conditions.