银翘散合麻杏石甘汤加减配合磷酸奥司他韦治疗甲型H1N1流感临床研究

Clinical study on treatment of H1N1 Influenza with Yinqiaosan and Maxing Shigan decoction combined with Oseltavir phosphate

目的探讨银翘散合麻杏石甘汤加减与磷酸奥司他韦联合用于甲型H1N1流感治疗的临床价值。方法按照随机数字表法将北京市房山区中医医院76例甲型H1N1流感患者(2015年2月—2018年5月期间收治)分为观察组与对照组,每组38例。常规对症治疗基础上,对照组给予磷酸奥司他韦治疗,观察组在上述基础上再联合银翘散合麻杏石甘汤加减治疗,两组均连续治疗5 d。对比两组临床疗效、症状及体征改善情况、治疗期间不良反应发生率。结果观察组治疗总有效率94.74%(36/38)高于对照组78.95%(30/38)(P<0.05);观察组退热时间、咳嗽、咽部充血、乏力、全身酸痛症状消失时间及咽拭子转阴时间短于对照组(P<0.05);两组头痛、咳痰、鼻塞、流涕症状消失时间比较,差异无统计学意义(P>0.05);治疗期间,观察组恶心/呕吐、头晕、失眠等不良反应发生率与对照组比较无显著差异(P>0.05)。结论银翘散合麻杏石甘汤加减配合磷酸奥司他韦治疗甲型H1N1流感,效果显著,有利于促进症状、体征转归,安全性亦有保证。

Objective To investigate the clinical value of Yinqiao San and Maxing Shigan Decoction combined with oseltamivir phosphate for the treatment of influenza A(H1 N1).Methods Seventy-six patients with influenza A(H1 N1)(from February 2015 to May 2018)were divided into observation group and control group according to the random number table method,38 cases in each group.On the basis of conventional symptomatic treatment,the control group was treated with oseltamivir phosphate.The observation group was combined with Yinqiaosan and Maxing Shigan Decoction on the above basis.The two groups were treated continuously for 5 days.The clinical efficacy,symptoms and signs of improvement and the incidence of adverse reactions during treatment were compared between the two groups.Results The total effective rate of the observation group was 94.74%(36/38)higher than that of the control group 78.95%(30/38).Observed the antipyretic time,cough,pharyngeal congestion,fatigue,and body aching symptoms disappeared in the observation group.The time of throat swabs was shorter than that of the control group(P<0.05).There was no significant difference in the disappearance time of headache,cough,nasal congestion and salivation between the two groups(P>0.05).During the treatment,the incidence of adverse reactions such as vomiting,dizziness and insomnia in the observation group was not significantly different from that of the control group(P>0.05).Conclusion Yinqiaosan and Maxing Shigan Decoction combined with oseltamivir phosphate for the treatment of influenza A H1 N1 has a significant effect,which is conducive to promoting the symptoms and physical signs,and the safety is also guaranteed.