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红花黄色素氯化钠注射液联合酒石酸美托洛尔对不稳定型心绞痛患者心电图及血清MCP-1、MMP-9水平的影响 被引量:5

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摘要 目的探讨红花黄色素氯化钠注射液联合酒石酸美托洛尔对不稳定型心绞痛(UAP)患者心电图及血清单核细胞趋化蛋白-1(MCP-1)、基质金属蛋白酶-9(MMP-9)水平的影响。方法选取2017年1月—2018年8月河南圣德医院UAP患者100例,随机数字表法分组,各50例。对照组予以酒石酸美托洛尔,研究组予以酒石酸美托洛尔+红花黄色素氯化钠注射液,治疗时间为14 d。观察两组疗效,对比治疗前后心电图变化[12导联心电图ST段压低≥2.5 mm导联数(NST)、12导联ST段压低数值总和(ΣST)]、血清MCP-1及MMP-9水平。结果研究组治疗总有效率为96.00%,高于对照组76.00%(P<0.05);与对照组比较,治疗后研究组NST较少,ΣST较低(P<0.05);与对照组比较,治疗后研究组MCP-1、MMP-9水平较低(P<0.05)。结论 UAP采取红花黄色素氯化钠注射液与酒石酸美托洛尔联合治疗,可降低血清MCP-1、MMP-9水平,改善心电图,提高治疗效果。
作者 周振
出处 《医药论坛杂志》 2019年第2期147-149,共3页 Journal of Medical Forum
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  • 1李德云,马礼坤.急性冠脉综合征的诊断与治疗进展[J].国外医学(老年医学分册),2007,28(4):173-177. 被引量:19
  • 2Libby P. Inflammation and cardiovascular disease mechanisms[J]. Am J Clin Nutr,2006,83(2):456S60S.
  • 3Kaptoge S,Seshasai SR,Gao P,et al. Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta- analysis[J]. Eur Heart J,2014,35(9):578-89.
  • 4Welsh P,Whincup PH,Papacosta O,et al. Serum matrix metalloproteinase-9 and coronary heart disease: a prospective study in middle-aged men[J]. QJM,2008,101(lO):785-91.
  • 5E1-Mesallamy HO,Hamdy NM,E1-Etriby AK,et al. Plasma granzyme B in ST elevation myocardial infarction versus non-ST elevation acute coronary syndrome: comparisons with IL-18 and fractalkine[J]. Mediators Inflamm,2013,2013:343268.
  • 6Klinghammer L,Urschel K,Cicha I,et al. Impact of telmisartan on the inflammatory state in patients with coronary athcrosclerosis--influence on IP-10, TNF-c and MCP-I[J]. Cytokine,2013,62(2):290-6.
  • 7Fraker TD Jr, Fihn SD,2002 Chronic Stable Angina Writing Committee,et al. 2007 chronic angina focused updale of the ACC/AHA 2002 guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 guidelines for the management of patients with chronic stable angina[J]. J Am Coll Cardiol,2007,50(23):2264-74.
  • 8Andel'son JL,Adams CD,Antman EM,et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction:a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (writing committee to revise the 2002 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction) developed in collaboration with the American College of Emergency Physicians,the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine[J]. J Am Coil Cardiol,2007,50(7):e I -e 157.
  • 9Kushner FG,Hand M,Smith SC Jr,et al. 2009 focused updates: ACC/ AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 ofideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines[J]. J Am Coil Cardiol,2009,54(23):2205-41.
  • 10Umehara H,Bloom ET, Okazaki T,et al. Fractalkine in vascular biology: from basic research to clinical disease[J]. Arterioscler Thromb Vasc Biol,2004,24( l ):34-40.

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