注射用鼠神经生长因子18μg肌肉注射联合注射用甲泼尼龙琥珀酸钠治疗外伤性视网膜视神经挫伤临床研究

Clinical study on treatment of traumatic retinal optic nerve contusion by injection of mouse nerve growth factor 18μg intramuscular injection combined with injection of methylprednisolone sodium succinate

目的探究注射用鼠神经生长因子18μg肌肉注射联合注射用甲泼尼龙琥珀酸钠治疗外伤性视网膜视神经挫伤的临床效果。方法选取2016年6月—2018年4月平顶山市第一人民医院外伤性视网膜视神经挫伤40例(40眼),随机数字表法分为观察组与对照组,各20例(20眼)。对照组给予注射用甲泼尼龙琥珀酸钠治疗,观察组给予注射用鼠神经生长因子18μg肌肉注射+注射用甲泼尼龙琥珀酸钠。观察比较两组治疗效果、治疗1个月后视野变化[视野平均缺损(MD)、平均光敏感度(MS)]。结果观察组总有效率90.00%高于对照组(60.00%,P<0.05);治疗1个月后观察组MS、MD优于对照组(P<0.05)。结论注射用鼠神经生长因子18μg肌肉注射联合注射用甲泼尼龙琥珀酸钠治疗外伤性视网膜视神经挫伤效果显著,可有效减轻视野缺损,改善视神经,促进病情恢复。

Objective To investigate the clinical effect of 18μg intramuscular injection of mouse nerve growth factor combined with injection of methylprednisolone sodium succinate in the treatment of traumatic retinal optic nerve contusion.Methods Forty patients(40 eyes)with traumatic retinal optic nerve contusion in our hospital from June 2016 to April 2018 were randomly divided into observation group and control group,20 cases(20 eyes).The control group was treated with methylprednisolone sodium succinate for injection,and the observation group was given intramuscular injection of 18μg of nerve growth factor for injection+sodium methylprednisolone sodium succinate for injection.The therapeutic effects of the two groups and the visual field changes after 1 month of treatment[average visual field defect(MD),mean light sensitivity(MS)]were compared.Results The total effective rate of the observation group was 90.00%higher than that of the control group(60.00%,P<0.05).After 1 month of treatment,the MS and MD of the observation group were better than the control group(P<0.05).Conclusion Intramuscular injection of mouse nerve growth factor 18μg combined with injection of methylprednisolone sodium succinate is effective in treating traumatic retinal optic nerve contusion,which can effectively reduce visual field defects,improve optic nerve and promote disease recovery.