原发性肝癌TACE术灌注康莱特对AFP的影响观察

Observation on the Effect of Hepatocellular Carcinoma with TACE Perfusion of Kanglaite on the AFP

目的观察原发性肝癌TACE术灌注康莱特对甲胎蛋白(AFP)的影响及其治疗效果。方法随机选取我院收治的肝癌肝动脉化疗栓塞术(TACE)患者60例,依据治疗方法分为术后灌注康莱特注射液组(观察组)和术后未灌注康莱特注射液组(对照组)各30例,对两组患者不同时间点的血清胸苷激酶1(Tk1)和AFP水平、临床疗效进行统计分析。结果两组患者的血清Tk1水平随着时间的后移逐渐降低(P<0.05);T1、T2、T3、T4时观察组患者的血清Tk1水平均显著低于对照组(P<0.05),但T0时两组患者的血清Tk1水平之间的差异不显著(P>0.05);两组患者的血清AFP水平随着时间的后移逐渐降低(P<0.05);T1、T2、T3、T4时观察组患者的血清AFP水平均显著低于对照组(P<0.05),但TO时两组患者的血清AFP水平之间的差异不显著(P>0.05);观察组患者的总缓解率40.0%显著高于对照组23.3%(P<0.05)。结论原发性肝癌TACE术后灌注康莱特注射液能够有效降低患者的血清AFP水平,改善患者的临床疗效。

Objective To observe the influence of hepatocellular carcinoma with TACE perfusion of Kanglaite on alphafetoprotein(AFP) and its clinical effect. Methods 60 cases of patients with liver cancer TACE operation were randomly divided into postoperative perfusion Kanglaite group(observation group, n=30) and no postoperative perfusion Kanglaite injection group(control group, n=30) according to the treatment methods, the serum AFP and Tkl levels on different time points, clinical efficacy of the two groups were statistically analyzed. Results The serum Tkl levels of the two groups were gradually decreased along with the time shift(P<0.05);the serum Tkl levels of T1, T2, T3, T4 of observation group were significantly lower than control group(P<0.05),but the difference of serum Tkl levels of TO between the two groups were not significant(P>0.05).The serum AFP levels of the two groups decreased gradually along with the time shift(P<0.05);the serum AFP levels of T1, T2, T3, T4 of observation group was significantly lower than control group(P<0.05), but the difference of serum AFP levels of TO between the two groups were not significant(P>0.05).The total remission rate of observation group was 40.0%, significantly higher than23.3% of control group(P<0.05). Conclusion Kanglaite injection perfusion can effectively reduce the serum AFP level and improve the clinical efficacy of patients with primary liver cancer after TACE.