仙芪养络安喘方治疗慢性持续期支气管哮喘临床观察

Clinical Observation on Xianqi Yangluo Anchuan Decoction in Treatment of Chronic Persistent Bronchial Asthma

目的观察仙芪养络安喘方治疗慢性持续期支气管哮喘的临床疗效。方法将84例慢性持续期支气管哮喘患者随机分为对照组和治疗组,对照组予以西医常规治疗,疗程为1年。治疗组在西医常规治疗基础上加用仙芪养络安喘方治疗2个疗程,共8周。结果治疗组总有效率为92.86%,高于对照组的85.71%(P<0.05);两组治疗后哮喘控制测试问卷评分(ACT评分)和6min步行距离(6MWD)均较治疗前明显提高,但治疗组提高更为明显(P<0.05);两组治疗后年均急性发作次数和年均住院次数均较治疗前减少,治疗组减少更明显(P<0.05或0.01);两组治疗后用力肺活量(FVC)、第1秒用力呼气容积(FEV1.0)、1秒率(FEV1.0/FVC)、峰流速(PEF)等均较治疗前改善,治疗组改善程度优于对照组(P<0.05或0.01)。结论仙芪养络安喘方能明显减轻慢性持续期支气管哮喘患者的症状和体征,提高患者运动耐力,降低未来急性发作或住院的风险,改善肺功能,提高患者生活质量。

Objective To observe the clinical efficacy of Xianqi Yangluo Anchuan decoction in treatment of chronic persistent bronchial asthma.Methods 84 cases of patients with chronic persistent bronchial asthma were randomly divided into treatment group and control group.Control group was treated with routine western medicine for 1 year.Treatment group was given 2 courses of treatment for 8 weeks with Xianqi Yangluo Anchuan decoction on the basis of control group.Results The total effective rate of treatment group was 92.86%,higher than that of control group 85.71%(P<0.05).After treatment,the asthma control test questionnaire score(ACT score)and 6-minute walking distance(6 MWD)of both groups were significantly higher than those before treatment,and the improvement of treatment group was more obvious(P<0.05).The average number of acute attacks and average annual hospitalization in both groups were less than those before treatment,the decrease in treatment group was more obvious(P<0.05 or P<0.01).Forced expiratory volume(FVC),Force exhalation volume in the 1st second(FEV1.0),FEV1.0/FVC and Peak expiratory flow(PEF)in both groups were improved compared with those before treatment,and the improvement in treatment group was more obvious than that in control group(P<0.05 or P<0.01).Conclusion Xianqi Yangluo Anchuan decoction can significantly reduce the symptoms and signs of chronic persistent bronchial asthma patients,improve exercise endurance,reduce the risk of future acute attack or hospitalization,improve lung function and improve the quality of life of patients.