自拟散溃方治疗复发性口腔溃疡疗效及对微生物菌群的影响

Effect of Self-made Sankui Prescription Combined with Lidocaine on Recurrent Oral Ulcer and Microbial Flora

目的观察自拟散溃方对复发性口腔溃疡患者疗效及微生物菌群的影响。方法以我院收治的62例复发性口腔溃疡为研究对象,按随机数字表法分为观察组和对照组,每组31例。对照组采用左旋咪唑和维生素西医常规治疗,观察组在对照组基础上联合自拟散溃方进行治疗。比较两组的临床疗效及微生物菌群数量的变化。结果治疗后观察组的有效率(96.8%)高于对照组(66.7%),治疗后观察组中溃疡持续时间(3.25±0.98)d少于对照组(4.17±1.23)d;差异均具有统计学意义(均P<0.05)。治疗后观察组的口腔链球菌、韦荣氏菌及奈瑟氏菌数量均高于对照组,差异均具有统计学意义(P<0.05)。结论联合西医常规疗法应用自拟散溃方治疗复发性口腔溃疡患者临床效果较为显著,能够较好地恢复口腔微生物菌群平衡状态。

Objective To observe the effect of self-made Sankui prescription on recurrent oral ulcer and microbial flora.Methods 62 cases of patients with recurrent oral ulcers were randomly divided into observation group and control group,31 cases in each group.Control group was treated with levamisole and vitamins.Observation group was treated with self-made Sankui prescription on the basis of control group.The clinical efficacy and the population of microbial flora were compared between the two groups.Results After treatment,the effective rate of observation group was higher than that of control group,and the ulcer duration(3.25±0.98)d was less than that of control group(4.17±1.23)d;the difference was statistically significant(P<0.05).The number of oral streptococci,Veroniella and Neisseria in observation group was higher than those in control group,the difference was statistically significant(P<0.05).Conclusion Self-made Sankui prescription is effective in treatment of patients with recurrent oral ulcers,and the balance of oral microbial flora can be better restored.