某院手足口病标本病毒检测结果探讨

Study the Virus Detection Results of Specimens of Hand, Foot and Mouth

目的探讨该院手足口病标本病毒检测结果观察。方法回顾性分析2014年4—7月在该院治疗的300例手足口病患者的临床资料,分别采用咽拭子标本和粪便标本进行病原学检测,分析检测结果。结果所有患者中,肠道病毒(EV)检出率为90.67%,其中肠道病毒71型(EV71)占62.13%,柯萨奇病毒A16(CA16)占16.18%,其他EV亚型占21.69%;粪便标本EV71检出率高于咽拭子标本,差异有统计学意义(P<0.05);男女比例无明显差异,发病主要集中在1~3岁,达76%,尤以1岁内发病率最高,达48.67%。结论手足口病由感染EV引起,以EV71和CA16最为高发,粪便标本的检出率更高,加强EV71和CA16的检测有助于提高手足口病的防范和控制。

Objective To investigate the virus detection results of specimens of hand, foot and Mouth. Methods The clinical data of 300 cases with hand, foot and mouth disease which were treated in our hospital during April 2014 to July 2014 were retrospectively analyzed, the throat swab specimens and the stool specimens were respectively used to detect the pathogen, and the results were analyzed. Results All patients, the enterovirus(EV) detection rate was 90.67%, the type of enterovirus 71(EV71) accounted for 62.13%, coxsackie virus A16(CA16) accounted for 16.18%, other EV subtype accounted for 21.69%; Stool specimens EV71 detection rate was higher than pharyngeal swab specimens, the difference was statistically significant(P < 0.05); Ratio of male to female was not significant difference, mainly concentrated in 1 to 3 years old, the incidence was up to76%, especially within 1year of age, up to 48.67%. Conclusion Hand, foot and mouth disease caused by infection with EV, EV71 and CA16 were the highest, and the feces specimen detection rate was higher, the detection of EV71 and CA16 was helpful to improve the prevention and control of hand foot mouth disease.