不同剂量西地那非治疗新生儿肺动脉高压的疗效

Different Dose of Sildenafil Curative Effect for The Treatment of Neonatal Pulmonary Hypertension

目的分析新生儿肺动脉高压患儿服用不同剂量西地那非的临床效果。方法随机选取2012年3月—2014年4月100例在该院接受治疗的肺动脉高压患儿,平均分为对照组和试验组,每组50例,对照组给予1.0 mg·(kg·d)-1西地那非,试验组给予2.0 mg·(kg·d)-1西地那非,对两组患儿的临床状况以及肺动脉压力、二氧化碳动脉血氧分压对比并研究。结果经过治疗后,试验组患儿治疗后肺动脉压力(25.00±4.5)mg·(kg·d)-1明显低于对照组患儿肺动脉压力(28.10±4.2)mm Hg;试验组二氧化碳血氧分压(35.30±4.4)mm Hg明显低于对照组二氧化碳血氧分压(48.10±5.6)mm Hg,两组差异具有统计学意义(P<0.05)。结论对于新生儿肺动脉高压,西地那非剂量有效增加,肺动脉压力降低效果更佳明显,呼吸困难及发绀症状有效缓解,值得临床广泛应用并加以推广。

Objective To analysis the newborn children with pulmonary hypertension take the clinical effect of different dose of sildenafil. Methods Select 100 cases from 2012 March to 2014 April in our hospital for treatment of children with pulmonary hypertension, the average is divided into control group and experimental group, and 50 people in each group, control group to 1.0mg·(kg·d)-1sildenafil, the experimental group to 2.0 mg·(kg·d)-1sildenafil, the clinical conditions of two groups of children, and pulmonary artery pressure, carbon dioxide, arterial blood oxygen partial pressure and comparison research. Results After treatment,the treatment group after treatment in children with pulmonary artery pressure(25.00 ±4.5) significantly lower than the control group with pulmonary artery pressure(28.10 ± 4.2); Experimental group carbon dioxide blood oxygen partial pressure(35.30 ±4.4)significantly lower than control group in blood oxygen partial pressure carbon dioxide(48.10 ±5.6), the difference between the two groups have statistical significance(P<0.05). Conclusion For neonatal pulmonary hypertension, sildenafil dose increase effectively,reduce pulmonary artery pressure better effect obviously, effective alleviate symptoms of dyspnea and cyanosis, worth clinical extensive application and promotion.