卷曲霉素联合对氨基水杨酸异烟肼治疗耐药结核病临床疗效探讨

The Clinical Curative Effect Observation of Capreomycin Combined with Pasiniazide to the Drug-resistant Tuberculosis Treatment

目的探讨用卷曲霉素联合对氨基水杨酸异烟肼治疗耐药结核病的疗效,用于指导临床用药。方法整群选取2012年12月—2014年12月该院收治的耐药结核病患者166例,随机分为治疗组和对照组,每组83例,将治疗组用卷曲霉素联合对氨基水杨酸异烟肼治疗,对照组仅用卷曲霉素治疗,进行疗效比较观察。结果治疗组显效52例(62.65%),总有效率89.16%;对照组显效34例(40.96%),总有效率66.26%。治疗组不良反应发生率是6.02%,而对照组不良反应发生率是12.05%。治疗组明显优于对照组,经统计学处理差异有统计学意义(P<0.05)。结论应用卷曲霉素联合对氨基水杨酸异烟肼治疗耐药结核病,安全有效,不良反应少,值得临床推广。

Objective To investigate the use of capreomycin combined with pasiniazide to the drug-resistant tuberculosis treatment, to guide clinical practice. Methods Choose 166 cases of drug-resistant tuberculosis patients from the December of 2012 to the December of 2014 in our hospital, we randomly divided into treatment group and control group, 83 patients in each group. The treatment group will be jointly capreomycin and pasiniazide,the control group only will be used capreomycin,then compare curative effect observation. Results The efficiency number of the treatment group is 52 cases(62.65%),the total effective rate is89.16%; The efficiency of the control group is 34 cases(40.96%), the total efficiency is 66.26%. The adverse reaction rate of the treatment group was 6.02%, while the incidence of adverse reactions in the control group was 12.05%. The treatment group is better than the control group, the difference was statistically significant(P<0.05). Conclusion Capreomycin combined with pasiniazide to the drug-resistant tuberculosis treatment is safe and effective, less adverse reaction, worthy of promotion.