脑脊液置换术治疗蛛网膜下腔出血的临床疗效探讨

Clinical Observation of the Effect of Exchange of Cerebrospinal Fluid for the Treatment of Subarachnoid Hemorrhage

目的为了进一步提高该院对蛛网膜下腔出血的治疗效果并减少各种不良事件的发生几率,探讨和研究在治疗过程中采取脑脊液置换术的安全性和意义。方法按照随机双盲对照的原则将2014年1月—2015年1月在菏泽市第二人民医院神经外科住院治疗的60例蛛网膜下腔出血患者作为研究对象并分为观察组和对照组,每组各包括患者30例,其中对照组患者在治疗的过程中应用常规方案进行,则观察组患者在常规治疗的基础上采取脑脊液置换术方案治疗,对比和分析两种不同的治疗方案的治疗效果和并发症发生几率。结果经过数据分析得出,观察组患者在7 d、14 d内头痛持续分别为8(26.67%)、3(10.00%),而对照组患者在7 d、14 d内头痛持续分别为20(66.67%)、12(40.00%),对照组患者效果明显不如观察组,且两组患者比较差异具有统计学意义(P<0.05)。结论对蛛网膜下腔出现患者在进行常规药物治疗的基础上实施脑脊液置换术治疗,不仅可以提高患者的治疗有效率,而且减少了各种并发症的发生几率,值得临床推广。

Objective To investigate the safety and significance of exchange of cerebrospinal fluid in the treatment of subarachnoid hemorrhage so as to further improve the therapeutic effect and reduce the incidence of adverse events in the treatment of the disease in our hospital. Methods 60 cases with subarachnoid hemorrhage underwent hospitalization in Department of Neurosurgery of Heze Second People’s Hospital from January 2014 to January 2015 were selected as the subjects and divided into the observation group and the control group with 30 cases in each in accordance with the random double-blind control principle. Patients in the control group were treated by the conventional regimen, while those in the observation group were treated by exchange of cerebrospinal fluid combined with the conventional regimen. And the therapeutic effect and incidence of complications were compared between the two groups. Results The analysis of the data showed that 8 cases(26.67%) in the observation group while 20 cases(66.67%) in the control group had headache lasting for 7d, 3 cases(10.00%) in the observation group while 12 cases(40.00%) in the control group had headache lasting for 14 d, the therapeutic effect of the observation group was much better than that of the control group with statistically significant difference(P<0.05). Conclusion For patients with subarachnoid hemorrhage, conventional drug therapy combined with exchange of cerebrospinal fluid can improve the response rate and reduce the incidence of complications, so it is worthy of clinical promotion.