肝细胞癌经动脉栓塞化疗术后急性肾损伤的危险因素研究

Risk Factors of Acute Kidney Injury Following Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

目的探讨肝细胞癌经导管动脉栓塞化疗术后急性肾损伤的相关危险因素。方法回顾性研究该院2010年1月—2015年1月接受动脉栓塞化疗术的318例患者的临床资料,以发生急性肾损伤为观察终点,将患者分为急性肾损伤组和非肾损伤组,对急性肾损伤发生相关的危险因素进行分析。结果 318例入组患者中,发生TACE后AKI共29例,发生率为9.1%。多因素Logistic回归分析结果显示,表明年龄>55岁(OR=3.34,95%CI:1.21~9.79)、谷草转氨酶>55 U/L(OR=4.53,95%CI:1.78~10.91)、糖尿病(OR=5.12,95%CI:1.58~11.90)是经动脉栓塞化疗术后急性肾损伤发生的独立危险因素。结论老年(年龄>55岁)、谷草转氨酶>55 U/L、糖尿病是经动脉栓塞化疗后急性肾损伤发生的独立危险因素。

Objective To investigate the risk factors of acute kidney injury(AKI) after transarterial chemoembolization(TACE) for hepatocellular carcinomas. Methods The clinical data of 318 patients undergoing TACE at our hospital from January 2010 to January 2015 were examined retrospectively. The occurrence of AKI was used as primary endpoint. The patients were divided into the AKI group and the non-AKI group. The incidence and risk factors of AKI was examined. Results Of the enrolled 318 patients, 29 patients had AKI, and the incidence was 9.1%. The results of Logistic regression showed that age >55 years(OR =3.34, 95% CI:1.21-9.79), aspartate aminotransferase level>55U/L(OR=4.53, 95%CI:1.78-10.91)and diabetes(OR=5.12, 95%CI:1.58-11.90)were associated with the development of AKI after TACE procedure. Conclusion Old age(age >55 years), aspartate aminotransferase level>55U/L and diabetes are the independent risk factors for post-TACE AKI development.