无创正压通气治疗急性重症心源性肺水肿的临床效果分析

Clinical Study of Non-Invasive Positive Pressure Ventilation in Treatment of Severe Acute Cardiogenic Pulmonary Edema

目的观察并分析无创正压通气治疗急性重症心源性肺水肿的临床效果。方法随机选取2013年2月—2015年3月该院收治的60例急性重症心源性肺水肿患者为研究对象,随机分为研究组和对照组,两组均采取常规药物治疗,研究组在此基础上采用无创正压通气治疗,观察并比较两组患者通气前和通气后体征、临床症状以及相关指标等的变化。结果经过1~4 h的无创通气治疗,患者的心率和呼吸频率与通气前相比明显减缓(P<0.001),平均动脉压明显下降(P<0.001),动脉血气分析的各项指标得到显著的改善(P<0.01),相关的临床症状也明显缓解,且研究组的治疗效果明显优于对照组(P<0.01),差异具有统计学意义。结论采用无创正压通气治疗急性重症心源性肺水肿可以迅速改善患者的低氧血症和心功能,有效缓解相关症状,心力衰竭病程缩短,是临床上治疗急性重症心源性肺水肿的有效治疗方法,值得推广和应用。

Objective To observe and explore the effect of non-invasive positive pressure ventilation in the treatment of severe acute cardiogenic pulmonary edema. Methods 60 patients with severe acute cardiogenic pulmonary edema admitted to our hospital from February 2013 to April 2015 were selected and randomly divided into study group and control group. The control group was given conventional drug therapy, while the study group underwent non-invasive positive pressure ventilation based on the methods used in the control group. The changes of clinical symptoms, complications and related parameters before and after treatment were measured. Results After 1-4 h treatment with non-invasive positive pressure ventilation for patients in the study group, their heart rate and respiration rate, and their mean arterial pressure, as well as parameters of arterial blood gases all decreased significantly,P <0.001, and decreased significantly, P <0.001, and related complications improved. Further more, the efficacy was significantly better in the study group than in the control group, and the difference was statistically significant difference, P<0.01. Conclusion Non-invasive positive pressure ventilation could improve hypoxemia and cardiac function, relieve symptoms in patients with severe acute cardiogenic pulmonary edema and shorten the course of heart failure. It is a safe and effective method for treating severe acute pulmonary edema, and is worthy of promotion.