吲达帕胺与非洛地平治疗高血压疗效与不良反应对比分析

Comparative Observation on Efficacy and Adverse Reactions in Treatment of Hypertension with Indapamide and Felodipine

目的研究分析吲达帕胺与非洛地平治疗高血压的临床效果和不良反应情况。方法整群选择2013年5月—2015年5月该院收治的高血压患者106例,随机分为对照组、观察组,各53例。对照组采用非洛地平治疗,观察组采用吲达帕胺治疗,比较分析两组临床治疗有效率、不良反应发生率、治疗前后动态血压及动态血压负荷值情况。结果观察组临床治疗有效率为96.23%,明显高于对照组的79.25%,差异有统计学意义(P<0.05);观察组不良反应发生率为1.89%,显著低于对照组的16.98%,差异有统计学意义(P<0.05);两组治疗后动态血压和动态血压负荷值显著低于治疗前,差异有统计学意义(P<0.05),观察组显著低于对照组,差异有统计学意义(P<0.05)。结论相比于非洛地平治疗,吲达帕胺治疗高血压具有显著的临床效果,能够有效缓解病情,且不良反应较少,更为安全可靠,值得推广。

Objective Analysis indapamide and felodipine hypertension clinical effects and adverse reactions. Methods Select 106 patients with hypertension from May 2013 to May 2015 in our hospital were randomly divided into control group, the observation group, 53 cases each. The control group, felodipine, observation group indapamide treatment, comparative effectiveness analysis of two clinical treatment, incidence of adverse reactions after treatment ambulatory blood pressure and ambulatory blood pressure load value situation. Results Effective clinical observation group was 96.23%, significantly higher than 79.25%, the difference was significant(P<0.05); the incidence of adverse reactions observed group of 1.89%, significantly lower than the 16.98% in the control group, the difference was significant(P<0.05); ambulatory blood pressure and ambulatory blood pressure load values after treatment was significantly lower than before treatment, the difference was significant(P<0.05), the observation group was significantly lower than the control group, the difference was significant(P<0.05). Conclusion Compared to felodipine, indapamide treatment of hypertension has a significant clinical effect, can effectively alleviate the condition, and fewer adverse reactions, more secure and re-liable, worthy of promotion.