神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病疗效分析

Hypoxic Ischemic Encephalopathy Combined with Naloxone Treatment Efficacy Ganglioside

目的研究分析神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病的临床效果。方法随机选取2012年9月—2014年9月该院收治的70例新生儿缺氧缺血性脑病患者,随机分为对照组、观察组,各35例。对照组给予常规治疗,观察组给予神经节苷脂联合纳洛酮治疗,比较分析两组的临床治疗有效率和新生儿神经行为测定评分(NBNA)情况。结果观察组临床治疗总有效率为97.14%,明显高于对照组的77.14%,差异有统计学意义(P<0.05);观察组治疗第5、10天NBNA评分显著高于对照组,差异有统计学意义(P<0.01)。结论神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病具有较高的临床治疗效果,能够有效提高临床疗效,改善患儿病情,值得推广。

Objective To study the analysis ganglioside combined with naloxone treatment of neonatal hypoxic-ischemic encephalopathy clinical results. Methods From September 2012 to September 2014 in our hospital 70 cases of neonatal hypoxic-ischemic encephalopathy were randomly divided into two groups, the observation group, 35 cases each. The control group received conventional treatment, observation group ganglioside combined with naloxone, comparative analysis of the two groups of clinical effectiveness and neonatal behavioral neurological assessment scores(NBNA) situation. Results The clinical total effective rate was97.14%, significantly higher than 77.14%, the difference was significant(P <0.05); 5 and 10 days of observation group NBNA scores were significantly higher, the difference was significant(P <0.01). Conclusion Ganglioside combined with naloxone treatment of neonatal hypoxic-ischemic encephalopathy have high clinical effect, can effectively improve the clinical efficacy and improve the condition of children, worthy of promotion.