82例浅表淋巴结肿大病因分析

Causes of Superficial Lymph Nodes Enlargement: An Analysis of 82 Cases

目的分析总结浅表淋巴结肿大的主要病因。方法整群选择该院于2011年1月—2015年4月期间收治的以浅表淋巴结肿大为首发表现的82例住院患者作为研究对象,收集组织病理检查、免疫组化检查等检查结果,对浅表淋巴结肿大进行病因分析。结果该组82例患者中,良性肿大者26例(31.70%),恶性肿大者56例(68.29%),恶性肿大发生率高于良性。良性肿大者中,感染为主要病因,其百分比显著高于其他病因,差异有统计学意义(P<0.05)。恶性肿大者中,非霍奇金淋巴瘤百分比最高,显著高于其他病因,差异有统计学意义(P<0.05);白血病百分比次之,与其他病因相比,差异有统计学意义(P<0.05)。结论病程大于2周的浅表淋巴结肿大以恶性肿大为主,其中感染、非霍奇金淋巴瘤、白血病均为浅表淋巴结肿大的主要病因,提示临床诊断时,应结合实验室检查、组织病理检查等辅助手段,综合分析确定病因。

Objective To analyze the main causes of superficial lymph nodes(SLN) enlargement. Methods 82 inpatients with superficial lymph nodes enlargement as the primary manifestation admitted to this hospital between January 2011 and April 2014 were included in this study. The causes of this disease were analyzed according to the results of pathological examination and immunohistochemical examinations. Results Of all the 82 cases, 26(31.70%) were found with benign SLN enlargement and 56(68.29%)with malignant one, and the incidence of malignant SLN enlargement was higher. Infection was the main cause of benign SLN accounting for a higher percentage than other cause, P <0.05. Malignant SLN enlargement was mainly caused by non-Hodgkin’s lymphoma with obviously higher percentage that other cause, P<0.05; leukemia was the cause of SLN enlargement with percentage higher the remainder causes, P <0.05. Conclusion Malignant enlargement is the main type of SLN enlargement with course of more than 2 weeks, and the main causes of SLN enlargement include infection, non-Hodgkin’s lymphoma and leukemia.The results suggest that the clinical diagnosis should be combined with the laboratory examination and pathologic examination and other auxiliary means so as to comprehensively analyze the cause.