大剂量奥美拉唑治疗老年胃溃疡合并出血的疗效

Efficacy of High-Dose Omeprazole in the Treatment of Elderly Patients with Gastric Ulcer Complicated with Hemorrhage

目的探究大剂量奥美拉唑治疗老年胃溃疡合并出血的临床疗效。方法整群选取于2013年8月—2014年8月在该院治疗的74例老年胃溃疡患者,随机将其分为观察组与对照组,对照组患者给予常规剂量的奥美拉唑进行治疗,观察组患者给予大剂量的奥美拉唑进行治疗,观察治疗以后的临床效果。结果观察组总出血率为5.4%,低于对照组的37.8%,组间比较差异具有统计学意义(P<0.05);观察组总有效率为97.3%,与对照组的81.0%相比明显较高,差异有统计学意义(P<0.05)。结论大剂量的奥美拉唑在治疗老年胃溃疡合并出血具有良好的临床效果。

Objective To analyze the curative effect of high-dose omeprazole in the treatment of elderly patients with gastric ulcer complicated with hemorrhage. Methods 74 aged patients with gastric ulcer treated in this hospital from August2013 and August 2014 were included and randomly divided into observation group and control group. Patients in the control group were treated with conventional-dose omeprazole, while those in the observation group were treated with high-dose omeprazole. The clinical outcomes of the treatment were observed. Results The overall rebleeding rate(5.4% vs 37.8%) was lower in the observation group than in the control group, and the difference between the two groups was statistically significant, P<0.05; the overall effective rate was 97.3% in the observation group and 81.0% in the control group, and the difference was statistically significant, P<0.05. Conclusion High-doses omeprazole for the treatment of elderly patients with gastric ulcer complicated with hemorrhage can bring good clinical effect.