第二版超声BI-RADS分级与乳腺癌免疫组化指标研究

Study on the Second Edition of BI-RADS and Immunohistochemical Markers of Breast Cancer

目的对第二版超声BI-RADS分级与乳腺癌免疫组化指标的研究。方法整群选取当地某医院2013年10月—2015年1月期间收集87例病理确诊乳腺癌的患者,使用免疫组化的相关方法并运用统计学原理观察。结果乳腺癌肿块内有毛刺组的ER、PR阳性表达率为86.0%(43/50)、84.0%(42/50)高于无毛刺组阳性表达率51.4%(19/37),48.6%(18/37)。两组进行对比,其差异有统计学意义(P=0.000 4和0.000 4,χ2=12.4661和12.4162)。有微钙化组的ER、PR阳性表达率54.5%(18/33)、51.5(17/33)%低于无微钙化组阳性表达率81.5%(44/54)、79.7%(43/54)。两组进行对比,其差异具有统计学意义(P=0.0011和0.0059,χ2=10.5333和7.5644)。结论第二版超声BI-RADS诊断乳腺癌的恶性征象与免疫组化五项指标(ER、PR、Ki-67、HER-2和P53)存在联系。

Objective To study the correlation between the second edition of BI-RADS grade and breast cancer immunohistochemistry index. Methods 87 patients with breast cancer were collected from October to 2015 2013, and the correlation was observed with immunohistochemistry. Results The positive expression rate of ER and PR in breast cancer was 86%(43/50) and 84%(42/50), 51.4%(19/37), 48.6%(18/37). The two groups were compared, the difference was statistically(P =0.0004 and 0.0004, and 12.4162 χ2=12.4661). The positive expression rate of ER and PR in the micro calcification group was 54.5%(18/33), 51.5(17/33), 81.5%(44/54) and 79.7%(43/54). The two groups were compared, the difference was statistically(P=0.0011 and 0.0059, and 7.5644 χ2=10.5333). Conclusion The second edition of BI-RADS in the diagnosis of breast cancer and the correlation between the malignant signs and the five indexes of immune system(PR, Ki-67, HER-2,P53 and ER).