男性2型糖尿病患者血糖与雄激素水平的相关性

Correlation between Blood Glucose and Androgen Levels in Male Patients with Type 2 Diabetes

目的通过研究男性2型糖尿病病人的糖化血红蛋白与血清雄激素水平的相关性,探讨男性2型糖尿病患者血糖与其血清雄激素水平的相关性。方法方便收集2015年1月—2017年12月上海市嘉定区安亭医院收治的110例男性2型糖尿病患者,测定其糖化血红蛋白(HbA1c)水平,血清睾酮(T)水平、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)。以T<14 nmol/L以及T≥14 nmmol/L分为两组,比较两组间的TC、TG、HbA1c、LDL-C、年龄的差异是否有统计学意义,并以T为因变量,TC、TG、HbA1c、LDL-C、年龄为自变量进行Logistic回归分析。结果 T<14 nmol/L组的HbA1c平均值为9.76%,平均年龄为57.64岁,T≥14 nmmol/L组的HbA1c平均值为8.28%,平均年龄为52.51岁,两组间的血清HbA1c以及年龄的差异有统计学意义(P<0.05),Logistic回归分析结果提示HbA1c与男性2型糖尿病患者的T值且呈负相关(r=-0.46, P<0.05)。结论男性2型糖尿病患者HbA1c与T水平相关, T水平的下降与血糖存在相关性。

Objective To investigate the correlation between glycosylated hemoglobin and serum androgen levels in male patients with type 2 diabetes, and to explore the correlation between blood glucose and serum androgen levels in male patients with type 2 diabetes. Methods From January 2015 to December 2017, 110 male patients with type 2 diabetes were convenient collected from Anting Hospital of Jiading District, Shanghai, and their glycated hemoglobin(HbA1c) levels,serum testosterone(T) levels, triglycerides(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C).Based on the T <14 nmol/L and T ≥14 nmmol/L, these patients were divided into two groups. The difference of TC, TG,HbA1c, LDL-C and age between the two groups was statistically significant, and T was the dependent variable. Logistic regression analysis was performed for TG, HbA1c, LDL-C, and age. Results The mean value of HbA1c in the T<14 nmol/L group was 9.76%, the mean age was 57.64 years old, the mean value of HbA1c in the T≥14 nmmol/L group was 8.28%,and the mean age was 52.51 years old. Serum HbA1c and age between the two groups. The difference was statistically significant(P<0.05). Logistic regression analysis showed that HbA1c was negatively correlated with T value in male patients with type 2 diabetes(r=-0.46, P<0.05). Conclusion HbA1c is associated with T levels in male patients with type 2 diabetes, and the decrease in T levels is associated with blood glucose.