观察连续性肾脏替代治疗(CRRT)严重脓毒血症的疗效

Observation of the Efficacy of Continuous Renal Replacement Therapy(CRRT) for Severe Sepsis

目的探讨针对严重脓毒血症患者采取连续性肾脏替代治疗的临床效果。方法方便选取该院2017年1月—2018年2月期间治疗的严重脓毒血症患者84例作为研究对象,随机分为观察组、对照组。对照组患者采取血液灌流方案实施治疗,而观察组患者则采取连续性肾脏替代治疗,比较两组患者的治疗效果。结果治疗后观察组患者的APACHEⅡ下降至(7.39±1.86)分,低于对照组的(13.22±3.71)分,(t=3.296,P=0.000<0.05);SOFA评分下降至(2.20±0.52)分,低于对照组的(5.13±1.24)分(t=7.082,P=0.000<0.05);尿素氮水平下降至(12.32±2.64)mmool/L,低于对照组的(19.17±3.06)mmool/L,(t=6.524,P=0.000<0.05);肌酐水平下降至(145.24±18.76)μmool/L,低于对照组的(192.06±22.35)μmool/L(t=4.192,P=0.000<0.05);PT和APPT水平均显著上升,并且观察组患者的改善效果显著好于对照组患者(t=5.162,6.282, P=0.000,P<0.05)。结论针对严重脓毒血症患者采取CRRT治疗可迅速缓解患者病情,并改善其凝血功能与肾功能,临床效果显著提升。

Objective To investigate the clinical effect of continuous renal replacement therapy in patients with severe sepsis. Methods 84 patients with severe sepsis treated in our hospital from January 2017 to February 2018 were convenient randomly divided into observation group and control group. The patients in the control group were treated with a blood perfusion protocol, while the patients in the observation group were treated with continuous renal replacement therapy to compare the therapeutic effects of the two groups. Results After treatment, the APACHE II of the observation group decreased to(7.39±1.86)points, which was lower than that of the control group(13.22±3.71)points,(t=3.296, P=0.000<0.05);the SOFA score decreased to(2.20±0.52)points. lower than the control group(5.13±1.24) points(t=7.082, P=0.000<0.05);the urea nitrogen level decreased to(12.32±2.64)mmol/L, lower than the control group(19.17±3.06)mmol/L,(t=6.524, P=0.000<0.05);creatinine level decreased to(145.24±18.76)μmol/L, lower than that of the control group(192.06±22.35)μmol/L(t=4.192, P=0.000 <0.05);PT and APPT increased significantly, and the improvement effect of the observation group was significantly better than that of the control group(t=5.162,6.282, P=0.000,P<0.05). Conclusion CRRT treatment for patients with severe sepsis can quickly relieve the patient’s condition, improve their coagulation function and renal function, and significantly improve the clinical effect.