左卡尼汀联合百令胶囊治疗腹膜透析患者对微炎症状态、残余肾功能及营养状况的影响

Effect of L-carnitine Combined with Bailing Capsule on Microinflammation,Residual Renal Function and Nutritional Status in Peritoneal Dialysis Patients

目的分析腹膜透析患者应用左卡尼汀与百令胶囊联合治疗对残余肾功能、微炎症状态与营养状况的影响。方法便利选择该院2015年8月—2018年5月诊治的76例腹膜透析患者,随机分成研究组(38例)和对照组(38例)。对照组使用左卡尼汀治疗,研究组给予左卡尼汀结合百令胶囊治疗,比较两组治疗效果。结果研究组治疗后Scr(565.32±112.31)μmol/L、Ccr(30.08±1.63)mL/min、BUN(13.97±0.84)mmol/L,优于对照组(t=4.444 4、8.307 3、7.063 2,P<0.05);研究组TNF-α(7.32±2.16)ng/L、IL-6 (12.86±1.52)ng/L、CRP (6.13±1.87)mg/L低于对照组(t=2.197 7,5.5227,7.155 5,P<0.05);研究组PA、Alb、Hb、TRF均高于对照组(t=3.181 7,7.327 6,2.567 2,3.298 6,P<0.05)。结论百令胶囊与左卡尼汀联合治疗腹膜透析患者的疗效确切,可有效改善残余肾功能,减轻微炎症状态,提升患者营养状况。

Objective To analyze the effects of combined treatment with L-carnitine and Bailing Capsule on residual renal function, microinflammation and nutritional status in peritoneal dialysis patients. Methods Convenient select 76 patients with peritoneal dialysis who were treated in the hospital from August 2015 to May 2018 were randomly divided into study group(38 cases) and control group(38 cases). The control group was treated with L-carnitine, and the study group was treated with L-carnitine combined with Bailing Capsule. The therapeutic effects of the two groups were compared. Results The Scr(565.32±112.31) μmol/L, Ccr(30.08±1.63)mL/min and BUN(13.97±0.84) mmol/L were better in the study group than in the control group(t=4.444 4,8.307 3, 7.063 2,P<0.05);TNF-α(7.32±2.16) ng/L, IL-6(12.86±1.52) ng/L, and CRP(6.13±1.87) mg/L were lower in the study group than in the control group(t=2.197 7, 5.522 7,2.155 5,P<0.05);the study group PA, Alb, Hb, TRF were higher than the control group(t=3.181 7, 2.567 2, 7.327 6, 3.298 6,P<0.05). Conclusion Bailing Capsule combined with L-carnitine is effective in the treatment of peritoneal dialysis patients, which can effectively improve residual renal function, reduce micro-inflammation and improve the nutritional status of patients.