愈肺宁方在慢性阻塞性肺疾病稳定期患者中的应用价值

Application Value of Yufeining Recipe in Patients with Stable Chronic Obstructive Pulmonary Disease

目的探讨愈肺宁方在慢性阻塞性肺疾病稳定期患者中的应用效果。方法方便选取2016年10月—2017年10月该院门诊治疗的92例慢性阻塞性肺疾病稳定期患者进行前瞻性对照研究,按照就诊时间分组,对照组给予常规西医治疗,研究组加用中医愈肺宁方,均治疗8周。对比两组治疗效果与安全性。结果①治疗后,研究组、对照组证候积分分别为(3.65±0.84)分、(5.00±0.47)分,差异有统计学意义(t=9.512,P=0.000);②研究组证候改善总有效率为97.83%,高于对照组的82.61%,差异有统计学意义(χ2=4.434,P=0.035);③治疗后,研究组IL-2、IL-8、CRP水平分别为(4.06±0.62)g/L、(1.45±0.35)ng/mL、(2.05±1.10)mg/L,对照组则为(3.24±0.61)g/L、(2.03±0.84)ng/m L、(3.86±3.24)mg/L,差异有统计学意义(t=6.394、4.323、3.588,P=0.000、0.000、0.000);④治疗后,研究组FEV1%、FEV1/EVC水平分别为(68.00±11.32)%、(58.06±8.21)%,对照组则为(60.00±11.23)%、(51.34±7.52)%,差异有统计学意义(t=3.403、4.094,P=0.000、0.000);⑤治疗后,研究组6 min步行试验距离为(428.54±75.50)m,长于对照组的(395.21±62.02)m,差异有统计学意义(t=2.314,P=0.011);⑥两组均未出现明显不良反应。结论慢性阻塞性肺疾病稳定期采用愈肺宁方治疗的效果更为理想,能促使症状尽快缓解,减轻炎症反应,且不良反应少,值得推广应用。

Objective To investigate the effect of Yufeining Recipe on patients with stable chronic obstructive pulmonary disease. Methods Convenient select a total of 92 patients with stable chronic obstructive pulmonary disease who underwent outpatient treatment from October 2016 to October 2017 were enrolled in this study. The patients in the control group were treated according to the time of treatment. The control group was given conventional Western medicine treatment. Yufeining recipe was treated in the study group for 8 weeks. Compare the efficacy and safety of the two groups. Results 1.After treatment, the syndrome scores of the study group and the control group were(3.65±0.84) points and(5.00±0.47) points, the difference was statistically significant(t=9.512, P=0.000);2.the study group syndrome improvement of the total effective rate was 97.83%, which was higher than 82.61% of the control group. The difference was statistically significant(χ2=4.434, P=0.035). 3.After treatment, the IL-2, IL-8 and CRP levels of the study group were(4.06 ±0.62) g/L,(1.45 ±0.35) ng/mL,(2.05±1.10) mg/L, and control group(3.24±0.61) g/L,(2.03±0.84) ng/mL,(3.86±3.24) mg/L, the difference was statistically significant(t= 6.394, 4.323, 3.588, P=0.000, 0.000, 0.000);4.after treatment, the study group FEV1%, FEV1/EVC levels were(68.00 ±11.32)%,(58.06 ±8.21)%, the control group was(60.00 ±11.23)%,(51.34 ±7.52)%, the difference was statistically significant(t=3.403, 4.094, P=0.000, 0.000);5.after treatment, study group of distance of 6 min walking test was(428.54±75.50) m, which was longer than that of the control group(395.21±62.02) m. The difference was statistically significant(t=2.314, P=0.011). 6.There were no obvious adverse reactions in the 2 groups. Conclusion The effect of Yufeining recipe in the stable phase of chronic obstructive pulmonary disease is more ideal. It can promote the relief of symptoms as soon as possible, reduce the inflammatory reaction, and has fewer adverse reactions. It is worthy of popularization and application.