盐酸多奈哌齐联合用药方案延缓老年痴呆患者病情进展的作用

The Effect of Donepezil Hydrochloride Combined with Drug Regimen on Delaying the Progression of Senile Dementia Patients

目的探讨盐酸多奈哌齐联合用药方案延缓老年痴呆患者病情进展的作用。方法方便选取该院(2014年1月—2016年1月)收治的50例老年期痴呆患者为研究对象,两组患者均给予扩张冠状动脉、抗血小板、降糖、降压等常规治疗,观察组患者再口服盐酸多奈哌齐。对比两组患者治疗前后记忆力、智力状态、日常生活能力以及不良反应发生率。结果治疗后3个月、2年观察组患者WMS分别为(65.70±9.22)分、(70.94±7.22)分,MMSE评分分别为(18.45±4.11)分、(23.52±4.51)分。治疗后3个月、2年对照组WMS分别为(58.57±8.20)分、(52.40±7.20)分,MMSE评分分别为(14.46±4.08)分、(11.50±4.47)分,治疗3个月后,观察组明显高于对照组,差异有统计学意义(t=2.889 2、3.444 9,P<0.05)。治疗2年后,观察组明显高于对照组,差异有统计学意义(t=9.091 4、9.464 7,P<0.05)。治疗后2年观察组患者ADL评分良率24.00%明显高于对照组12.00%,差异有统计学意义(χ~2=4.878 0,P<0.05)。观察组患者不良反应发生率12.00%稍高于对照组8.00%,但均经对症处理后好转,差异无统计学意义(χ~2=0.888 9,P>0.05)。结论盐酸多奈哌齐联合用药方案延缓老年痴呆患者病情进展效果显著。

Objective To investigate the effect of donepezil hydrochloride combination regimen on delaying the progression of senile dementia patients.Methods A total of 50 elderly patients with dementia admitted to our hospital(January 2014 to January 2016)were convenient selected and enrolled.The patients in both groups were given conventional treatments such as dilatation of coronary artery,antiplatelet,hypoglycemia and hypotension.The patient was orally administered donepezil hydrochloride.The memory,mental state,daily living ability and incidence of adverse reactions were compared before and after treatment between the two groups.Results The WMS of the observation group at 3 months and 2 years after treatment were(65.70±9.22)points and(70.94±7.22)points,respectively,and the MMSE scores were(18.45±4.11)points and(23.52±4.51)points,respectively.The WMS of the control group at 3 months and 2 years after treatment were(58.57±8.20)points and(52.40±7.20)points,respectively,and the MMSE scores were(14.46±4.08)points and(11.50±4.47)points,respectively.After 3 months of treatment,the observation group was significantly higher than the control group,and the difference was statistically significant,(t=2.889 2,3.444 9,P<0.05).After 2 years of treatment,the observation group was significantly higher than the control group,and the difference was statistically significant(t=9.091 4,9.464 7,P<0.05).After 2 years of treatment,the ADL score of the observation group was 24.00%,which was significantly higher than that of the control group(12.00%).The difference was statistically significant(χ~2=4.878 0,P<0.05).The incidence of adverse reactions in the observation group was 12.00%slightly higher than 8.00%in the control group,but all of them improved after symptomatic treatment,which was not statistically significant(χ~2=0.888 9,P>0.05).Conclusion The combination of donepezil hydrochloride regimen has a significant effect on delaying the progression of senile dementia patients.