摘要
目的观察质子泵抑制剂雷贝拉唑钠对幽门螺杆菌的抑制作用。方法应用平板掺入法研究雷贝拉唑钠(波利特)对幽门螺杆菌的体外抑菌作用。结果 发现雷贝拉唑钠在体外对幽门螺杆菌具有明显的抑菌作用(MIC99为2.25μg/ml),其体外抑菌作用强于奥美拉唑(洛赛克)。结论本研究结果提示雷贝拉唑钠对幽门螺杆菌的直接抑菌作用可能在幽门螺杆菌感染的治疗中有重要作用。
Objective Rabeprazole is a gastric parietal. cell proton pump inhibitor, the aim of this study was to investigate its activity against Helicobacter pylori in vitro. Method We investigated its and imicrobial effect by deter- mining the MICs for 3H. pylori strains isolated from different ountries. Results The MIC99 was 2.25μg/ml for all the 3 strains, exhibiting a stronger inhibitory activity in vitro than Omeprazole. Conclusion It suggested that Rebaprazole contributed in the treatment of H. pylori infection not only for its anti - secretion of acid but also for its anti H. plori activity.
出处
《疾病监测》
CAS
2002年第12期452-454,共3页
Disease Surveillance
