大骨节病患者的婚育调查及SCE分析

The investigation of pregnancy of patients with Kishin-Beck disease and analysis of SCE.

目的 为了解大骨节病患者在婚育过程中 ,有无遗传性疾病发生及此类患者是否有细胞遗传学损伤情况。方法应用患者的静脉血淋巴细胞培养 ,制备SCE标本进行分析 ,同时对其婚育情况进行调查。结果 发现大骨节病患者的子女智力低下患病率 (4 9%) ,明显高于非患病区 (0 85 %) ,且SCE率分析与未患子女及正常对照人群有着显著性 (P <0 0 5)和非常显著性差异 (P <0 0 1 )。结论 大骨节病区患者有DNA损伤情况 ,建议患者子女婚配时不要患区及患者子女间婚配 。

Objective: To know the occurrence of hereditary disease and deficiency of cytogenetics in the coures of pergnancy patients with Kashin-Beck disease.Methods: The SCE samples were made with the cultured lymph cells in the patients′ blood of veins and these samples were analysed. At the same time,the conditions of theses patients′ pregnancy were investigated. Results: The rate of low intelligence among the children born by the patients with Kashin-Beck disease(4 9%)is higher than those born by non-patients(8 5%).And the rate of SCE has obvious difference between patients′ children and normal children(P<0 05).The same conclusion has also been found between the patients′ children and normal contrast people(P<0 01%).Conclusion: The patients lived in the Kashin-Beck disease area have DNA deficiency.And we suggest that patients′ children should not marry to the people lived in the disease area so as to reduce the infant with hereditary disease.