期刊文献+

氧自由基和牛磺酸在家兔休克再灌注损伤中的作用 被引量:4

Role of Oxygen Free Radical on Hemorrhagic Shock/Reperfusion and the Protection of Taurine
下载PDF
导出
摘要 探讨氧自由基 (OFR)在失血性休克再灌注损伤中的作用及牛磺酸的保护效应。健康家兔 2 4只随机分为 3组(n =8) :对照组、单纯休克组、牛磺酸治疗组 ;采用失血性休克再灌注损伤模型。连续观察休克前 ,休克 1.5h ,再灌注 1h、2h、3h时血浆超氧化物歧化酶 (SOD)活性、丙二醛 (MDA)含量、乳酸脱氢酶 (LDH)活性的动态变化 ;并测定再灌注 3h时心、肺组织MDA含量和SOD活性。结果显示 ,1)单纯休克组再灌注各时限MDA含量、LDH活性显著升高 ;SOD活性显著下降。 2 )再灌注 3h时心、肺组织MDA含量显著升高 ;SOD活性显著下降。 3)牛磺酸 (40mg·kg-1,iv)可减轻再灌注各时限上述指标的变化 (均P <0 .0 1)。提示OFR介导了休克再灌注损伤 ,牛磺酸对休克再灌注损伤的保护作用可能与减少OFR的生成和促进自由基的清除有关。 The paper investigates the role of oxygen free radical(OFR) in hemorrhagic shock/reperfusion injury and protective effect of taurine on it. Twenty four rabbits were divided randomly into 3 groups(n=8): control group,shock group,taurine group. The model of hemorrhagic shock/reperfusion was used. The activities of superoxide dismutase(SOD),lactate dehydrogenase(LDH)and the content of malondialdehyde(MDA)in plasma were observed before shock and shock 1.5 hours,reperfusion 1 hour,2 hours and reperfusion 3 hours. Meanwhile,the activities of SOD and the contents of MDA in lung and heart were measured at 3 hours reperfusion. Result show:1)The activities LDH and the contents of MDA increased significantly,but the activities of SOD decreased markedly in shock group during shock/reperfusion. 2)The contents of MDA in the lung and heart increased significantly,but the activity of SOD decreased markedly at 3 hours reperfusion. 3) Taurine(40 mg·kg\+\{-1\},iv) could attenuate all the changes mentioned above at total time points of reperfusion. These results suggested that OFR may be involved in the pathogenesis of shock/reperfusion,the protective effect of taurine on reperfusion injury might be related to decreasing the generation of OFR and strengthening scavenging of OFR.
出处 《石河子大学学报(自然科学版)》 CAS 2002年第4期276-278,共3页 Journal of Shihezi University(Natural Science)
关键词 氧自由基 牛磺酸 家兔 休克再灌注损伤 脂质过氧化 超氧化物歧化酶 保护效应 taurine shock reperfusion injury lipid peroxidation superoxide dismutase
  • 相关文献

参考文献6

二级参考文献13

  • 1赵东,刘平湖,付爱华,田青,谭敦勇,赵鸣武,唐朝枢.腐胺对大鼠油酸型呼吸窘迫综合征的防治作用[J].中华结核和呼吸杂志,1994,17(3):156-158. 被引量:4
  • 2石湘芸,姚松朝.牛磺酸的心肌细胞保护作用[J].中国药理学通报,1995,11(2):106-109. 被引量:21
  • 3魏重琴.超氧化物岐化酶肾上腺素自氧化测定法的研究[J].生物化学与生物物理进展,1988,15(2):124-126.
  • 4钟福孙 胡文尧 等.硫化巴比妥酸比色法测定血清过氧化脂质[J].临床检验杂志,1986,4:129-129.
  • 5石湘芸,中国药理学通报,1995年,11卷,2期,106页
  • 6宋德坤,中国病理生理杂志,1992年,8卷,6期,573页
  • 7巍重琴,生物化学与生物物理进展,1988年,15卷,2期,126页
  • 8钟福孙,临床检验杂志,1986年,4卷,129页
  • 9何芳,同济医科大学学报,1996年,25卷
  • 10颜崇超,基础医学与临床,1991年,11卷,126页

共引文献53

同被引文献39

引证文献4

二级引证文献48

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部