原发性胆囊癌CD44v6和bcl-2的表达及其与临床病理的关系

Study on the Relationship Between the Expression of CD44v6 and bcl-2 and Their Clinicopathologic Significance in Primary Gallbladder Cancer

目的 探讨CD44v6和bcl 2蛋白在原发性胆囊癌组织中的表达及其与癌组织类型、病理分级和转移状况的关系 ,以及CD44v6表达与bcl 2表达的相关性。方法 应用免疫组织化学方法检测 50例原发性胆囊癌、2 0例胆囊腺瘤和 1 0例慢性胆囊炎组织中CD44v6和bcl 2蛋白的表达。结果 胆囊癌组织中CD44v6和bcl 2表达阳性率分别为82 .0 %和 60 .0 % ,均明显高于胆囊腺瘤 (分别为 45 .0 %和 30 .0 % ,P<0 .0 5) ,并随着胆囊癌细胞分化程度的减低、病理分级的增高和转移而明显增高 (P<0 .0 5)。同时 ,CD44v6的表达与bcl 2表达呈正相关 (r =0 .36 ,P<0 .0 5)。结论 CD44v6和bcl 2均是胆囊癌高度恶性和预后不良的重要指标。胆囊癌CD44v6表达与bcl 2蛋白表达可能具有相互协同作用。

Objective To study the relationship of the expression of CD44v6 and bcl 2 protein with histological type,pathological grading and metastasis.Methods Immunohistochemical technique was used to investigate the expression of CD44v6 and bcl 2 in 50 primary gallbladder carcinoma,20 gallbladder adenoma and 10 chronic cholecystitis. Results The positive rate of CD44v6 and bcl 2 was 82.0% and 60.0%,which was positively correlated with the histological type,pathological grading and metastasis of gallbladder carcinoma( P <0.05) and was higher than that in gallbladder adenoma (CD44v6 45.0% and bcl 2 30.0% respectively).Expression of CD44v6 was significantly correlated with the expression of bcl 2( r =0.36, P <0.05).Conclusion CD44v6 and bcl 2 might be an important biologic marker to evaluate the malignancy and prognosis of gallbladder carcinoma.There might be some extent of coordinated regulation between them.