124例初诊骨髓增生异常综合征的骨髓象及骨髓活组织检查

Myelograms and Bone Marrow Biopsies of 124 Cases of Myelodysplastic Syndrome Diagnosed Initialy

目的 探讨初诊骨髓增生异常综合征 (MDS)病人的骨髓象及骨髓活组织检查结果。方法 对 12 4例确诊为MDS病人的骨髓象、临床表现、血液学检查结果及部分病人骨髓活组织检查结果进行分析。结果 12 4例病人均表现为贫血 ,部分还表现为全血细胞减少 ,骨髓象表现三系或二系或一系病态造血 ,骨髓活组织检查可见幼稚前期细胞异常定位(ALIP)。结论 诊断MDS的关键是病态造血 ,根据骨髓象特点排除其他相似疾病易诊断MDS ,同步进行骨髓活组织检查 ,能提高检出率。

Objective To probe into the results of myelograms and bone marrow biopsies in patients with myelodysplastic syndrome(MDS) diagnosed initialy.Method The clinical manifestations,results of myelograms,hematological test and bone marrow biopsies in 124 cases of MDS were analyzed.Results There was anemia in all 124 cases.In a part of them,there were pancytopenia.Abnormal locolization of infantile cell prophase(ALIP)of bone marrow biopsies and abnormal hematopoiesis of myelogram in three systems(RBC,WBC,PLT) or two or one were found.Conclusions Abnormal hematopoiesis is the key to the diagnosis of MDS.According to the myelogram,it could be diagnosed easily after eliminating other similar diseases.Synchronous bone marrow biopsies could raise the detective ratio.