摘要
目的 探讨西比灵治疗脑出血继发脑水肿的疗效及作用机制。方法 90例脑出血患者随机分为西比灵治疗组 5 0例 ,常规治疗对照组 40例 ,常规治疗组进行常规治疗 ,西比灵治疗组应用常规治疗 +西比灵 5mg ,每晚口服 ,共 2 0天 ,并分别在治疗前、治疗后 3、2 0天进行病情评分及ET 1、NSE测定并与对照组进行疗效对比。结果 (1)西比灵治疗组的临床疗效优于常规治疗组 (P <0 .0 5 ) ;(2 )西比灵治疗后ET 1、NSE浓度明显低于治疗前 (P <0 .0 1) ,随着病程的延长 ,二者血浆含量有下降趋势 ,与脑水肿密切相关。结论 (1)西比灵治疗脑出血继发脑水肿具有肯定疗效 ;(2 )ET 1、NSE血浆浓度测定可能成为脑出血继发脑水肿诊断及疗效评估的客观指标。
Objective To study the effectiveness and mechanism of sibelium treating cerebral edema secondary to hemorrhage.Method 90 cases of hemorrhage were divided into sibelium treating group(50 cases) and routine treating group(40 cases) randomly.The patients in sibelium group were given routine treatment plus sibelium 5mg oral every night for 20 days.The condition of patients in two groups was evaluated and the concentration of ET 1,NSE was determined before and 3,20 days after the treatment.The efficacy in two groups was compared.Results (1)The clinical effectiveness of sibelium group was superior to that of routine treating group.(2)The plasma concentration of ET 1,NSE after treatment with sibelium was lower than that before treatment( P <0.01) and decreased to the normal level basically along with the development of the disease.The concentration of ET 1,NSE was closly relative to the severity degree of cerebral edema.Conclusions (1)Sibelium has positive therapentic effect in treating hemorrhage.(2)The determination of ET 1,NSE concentration may become the objective experimental index for diagnosis and efficacy evaluation of cerebral edema secondary to hemorrhage.
出处
《现代诊断与治疗》
CAS
2003年第1期23-25,共3页
Modern Diagnosis and Treatment
