辽宁省0～14岁儿童格林-巴利综合征流行病学分析

Epidemiological analysis on guillain-barre syndrome(GBS) among children aged 0-14 years in Liaoning province

目的 分析辽宁省儿童格林 -巴利综合征 (GBS)的发病率、分布特征及可能的危险因素。方法 对辽宁省 1997～ 2 0 0 1年上报的 2 18例 0～ 14岁GBS病例进行个案调查 ,并进行统计分析。结果 辽宁省 0～ 14岁GBS报告发率为 0 65 / 10万 ,病死率为 4 1%。残留麻痹率为 5 5 4%。肠道病毒分离阳性率为 7 3 %。发病率存在季节差异 ,夏季发病率较高为 0 93 / 10万 ,冬季发病率较低为 0 4/ 10万 ,夏季、冬季发病率有显著性差异 (P <0 0 5 )。结论 肠道病毒感染及口服脊髓灰质炎疫苗可能是该病的一个诱因。辽宁省儿童GBS有很高的残留麻痹率 ,为 5 5 4% ,与应当引起临床医生。

Objective To analyze the incidence of Guillain-Barre Syndrome(GBS) and its characteristics in childhood (aged 0-14 years old) in Liaoning province and the latent risk factors.Methods To investigate 218 GBS cases reported by hospitals and analyze the information statistically.Results The average annual crude incidence reported was 0.65 per 100 000.The GBS case mortality was 4.1 percent.The residual paralysis was 55.4 percent.The positive isolation of enteroviruses was 7.3 percent.Study showed that the incidence varied in different season.The incidence in summer was 1.3 times higher than that in winter(0.93/100 000 vs 0.4/100 000, P <0 05).Conclusion The infection of enteroviruses and taking oral polio vaccines(OPV) may be the latent risk factors.The residual paralysis was so high that 55.4 percent of GBS cases could not recover completely.Others papers related to this subject reported that the residual paralysis was 15 percent.There was significant differnece between them ( P <0 05).It should be noticed greatly by clinic doctors,staff of EPI and parents of children.