被动吸烟与先天性唇腭裂关系的实验研究

An animal experiment on the association between passive smoking and cleft lip/palate

目的 探讨孕期被动吸烟与胎儿先天性唇腭裂发生的关系。方法 将SD大鼠随机分为不同的实验组及对照组 ,通过建立孕早、中、晚及全期被动吸烟模型进行对照研究。结果 :孕早、中及全期被动吸烟大鼠胎仔中有腭裂形成 ,阳性率分别为 1/ 48、2 / 5 3、1/ 3 6,对照组腭裂形成阳性率为 0 / 70。各实验组分别与对照组用四格表确切概率法检验 ,均无显著性差异 (P >0 .0 5 )。结论 孕期被动吸烟不能从统计学意义上证明与胎儿先天性唇腭裂发生有关 ,但不能排除孕早。

Objective Exploring the association between passive smoking during pregnancy and the incidence of cleft lip/palate in embryo and fetus.Methods SD rats were divided randomly into various experimental groups and control group and exposed at the early?middle?late and whole stage of pregnancy. Further to study the special maternal-fetal relationship by the animal experimental model.Results The experimental groups developed cleft palate at early?middle and whole stage of pregnancy. The incidence of the experimental groups were 1/48, 2/53, 1/36 respectively while the incidence of the control group was 0/70. Distinct statistic difference was not been found between each of the experimental groups and the control groups by Fisher's exact test ( P > 0.05 ).Conclusion The association between maternal passive smoking in pregnancy and the incidence of cleft lip/palate in fetus can not be proven by statistic methods, however, it can not exclude the effect of maternal passive smoking at early and middle in pregnancy on cleft palate in fetus.