摘要
在基因组时代 ,开发抗微生物的新药离不开基因组研究 ,基因组测序和生物信息学的迅猛发展使得微生物基因组上药物作用靶位的识别成为可能 ,并将使得细菌、真菌和寄生虫等对抗生素的耐药性成为过去。
Genome sequencing and bioinformatics is driving the discovery of drug targets and development of novel classes of broad spectrum antimicrobial compounds. The analysis of the complete genome sequences of microorganism available in the public databases offers the first insights into the drug targets discovery. This review discusses the use of genomic information in the finding of target genes for antimicrobial drug discovery.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2003年第1期9-12,共4页
Chinese Pharmacological Bulletin
基金
上海市科学技术发展基金资助项目 No 0 1JC 14 0 34
