系统性红斑狼疮患者血清中α-干扰素测定的临床意义

Clini cal significance of determination of serum interferon-áin patients with systemic lupus erythe-matosus

目的:探讨血清中α-干扰素(IFN-α)水平变化在系统性红斑狼疮(SLE)及狼疮性肾炎(LN)中的临床意义。方法:采用ELISA法对36例SLE患者(含29例LN患者)和10名正常对照者进行血清IFN-α水平检测,比较分析其与SLE活动指数(SLEDAI),肾脏组织病理活动指数(AI),抗dsDNA,补体C3,白细胞计数的相关性。结果:SLE患者血清IFN-α水平活动期为284.2pg/mL,静止期为160.3pg/mL,明显高于正常对照组121.8pg/mL(P<0.05),并且活动期高于静止期(P<0.01)。血清IFN-α水平与SLEDAI呈正相关(r=0.6101,P<0.05),AI≥8的患者为264.3pg/mL,明显高于AI<8患者的202.4pg/mL(P<0.01)。结论:检测SLE血清中IFN-α水平可作为活动敏感指标之一。

Objective:To investigate the clinical significance of se rum interferon-álevels in patients with systemic lu pus erythematosus(SLE). Methods:ELISA was used to evaluate serum interferon-álevels in36patients wi th SLE,includ-ing29lu pus nephritis(LN)and10normal controls.Results:Th e results revealed that serum interferon-álev el in SLE patients was higher th an that of normal control group (P<0.05).In addition,serum interferon-álevel of active SLE was high er than that of quiescent SLE(P<0.01).Th e level of serum interferon-áin SLE patients significantly correlated with SLE DAI score(r=0.6101,P<0.01).More over,serum interferon-álevel s in the patients with renal activity index(AI)≥8were significantly higher t han those in patients with AI<8(P<0.01).Conclusion:The study indicate s that serum interferon-álevel could be a sensitive index to the dis ease acti vity of SLE.