隐球菌性脑膜炎患者临床免疫指标分析

Analysis of clinical and immunologic parameters in patients with cryptococcal meningitis

目的:研究隐球菌性脑膜炎(隐脑)患者细胞和体液免疫功能。方法:用流式细胞仪和免疫扩散法检测了12例隐脑患者外周血T细胞亚群、NK细胞百分率及体液免疫指标。结果:与正常对照组相比,隐脑患者CD4+细胞百分率、CD4+/CD8+及C3均显著下降(P<0.01),血清中IgG下降(P<0.05)。结论:在非获得性免疫缺陷综合症(AIDS)隐脑患者同样存在着细胞免疫低下情况。

Objective:To evaluate the cellular a nd humoral immunity in patients with cryptococcal meningitis.Methods :T cell sub sets,the percentage of NK cells and the humoral immunologic parameters were det ermined with flow cytometry and immunodiffusion in12patients with cryptococcal meningitis.Results:The percentage of CD4 + cells,the ratio of CD4 +/CD8 + cells and the level of serum C3decreased signific antly(P<0.01),and the serum level of IgG also decreased(P<0.05)in patients with cryptococcal meningitis compared with those in the controls.Conc lusions :The results indicate that the cellu lar immunity in non-AIDS patients with cryptococcal meningitis is also lower than that of the healthy persons.