摘要
目的探讨血小板衍生生长因子 (PDGF)在小细胞肺癌 (SCLC)的表达。方法应用免疫组织化学技术观察了PDGF A链和PDGF B链在SCLC及肺非特异性炎症组织中的表达。结果SCLC组织中有PDGF A链显著过表达 (P =0 .0 0 7) ,而PDGF B链在两组间差异无显著性 (P =0 .111)。结论PDGF A链的异常表达可能与SCLC细胞增生有关 ,PDGF的两种多肽在SCLC中的生物特性可能有所不同。
Objective To investgate the expression of platelet derive growth factor (PDGF) in small cell lung cancer(SCLC). Methods The immunohistochemical methods were used to analyze the expression of PDGF A chain and PDGF B chain in 13 cases with SCLC, and in 8 cases with non specific inflammation of lung tissues. Results The excessive expression of PDGF A chain were found in SCLC ( P <0.05). There were no difference between SCLC and the inflammation control in PDGF B chain. Conclusion The biological specialities of the two piptide chains of PDGF could be different, the more expression of PDGF-A chain might be involved in the hyperplasia of SCLC.
出处
《贵州医药》
CAS
2003年第1期3-4,共2页
Guizhou Medical Journal
基金
贵州省卫生厅资助
