肺炎患儿血清嗜酸细胞阳离子蛋白含量变化和临床意义

Changes and clinical significance of serum eosinophil cationic protein levels in infant with pneumonia

目的 探讨嗜酸细胞阳离子蛋白 (ECP)在肺炎患儿体内含量的变化和临床意义。方法 随机选择在我院儿科住院的肺炎患儿 4 5例 ,根据临床表现分为 3组 ,喘息型肺炎急性期组 (Ⅰ组 ) 19例 ,非喘息型肺炎急性期组(Ⅱ组 ) 17例 ,喘息型肺炎恢复期组 (Ⅲ组 ) 9例 ;选择同期住院的 2 0例支气管炎急性期患儿 (Ⅳ组 )和 15例正常儿童 (Ⅴ组 )作对照 ,采用pharmaciaUniCAP检测系统分别对各组儿童的血清ECP含量进行检测。结果 5组儿童的血清ECP含量间差别有显著性意义 (P <0 0 5 )。结论 ECP参与肺炎喘息的发生 。

Objective To search the changes and clinical significance of eosinophil cationic protein (ECP) in pneumonia children.Methods 45 infants with pneumonia were randomly studied in three groups according to clinical features:groupⅠ,those in acute pneumonia with wheezing (n=19);group Ⅱ,those in acute pneumonia with no wheezing (n=17);group Ⅲ,those with wheezing pneumonia after treatment (n=9) and control group Ⅳ,those with acute bronchitis (n=20) and group Ⅴ,normal children (n=9).Serum ECP concentrations were measured by pharmacia UniCAP system.Results There were significant differences in serum ECP among five groups(P<0 05).Conclusion ECP appears to be an important factor in mechanism of pneumonia wheezing,involving in pathological procedure of wheezing.