肺癌组织中p63和Survivin蛋白的表达及其意义

Expression and Significance of p63 and Survivin Protein in Lung Carcinoma

[目的]研究p63和survivin两种蛋白在肺癌组织中的表达及其临床意义。[方法]通过免疫组织化学染色检测77例肺癌组织和10例非肿瘤性肺组织中的p63和survivin两种蛋白的表达及其与肺癌的组织类型、分化程度、复发转移和预后的关系。[结果]①10例非肿瘤性肺组织中,仅在支气管的假复层柱状上皮中见到P63的表达,未见survivin表达。②肺癌组织中p63的阳性细胞百分数为(51.7±32.7)％;其在无淋巴结转移组的阳性细胞百分数明显较淋巴结转移组低(P=0.010);p63的阳性细胞百分数与肿瘤大小、组织类型、分化程度、临床分期、复发和预后均无关(P>0.05)。③肺癌组织中survivin的阳性表达率为53.2％;其在复发组和淋巴结转移组的阳性表达率均明显高于无复发组和无淋巴结转移组(P=0.025和0.015);survivin(++～+++)组的生存期明显较(-～+)组短。[结论]p63和survivin均与肺癌的发生发展有关,survivin尤其与肺癌的复发、淋巴结转移有着密切关系,它的高表达提示肿瘤患者预后不良。

[Objective]To investigate the expression and significance of p63 and survivin protein in lung carcinoma. [Methods] The expression of p63 and survivin protein was detected in 77 cases of lung carcinoma and 10 cases of non-tumor lung tissue with immunohistochemistry. [Results]①Only p63 was found in the pseudostratified ciliated columnar epithelia of bronchi, and no survivin was found in all 10 cases of non-tumor lesions of lung.②2The percentage of p63 positive-stain cells of lung carcinomas was(51.7±32.7) % . The percentage of p63 in the non-metastasis group was significantly lower than that in the lymphoid node metastasis group ( P =0.010) . No relationship was found between the percentage and the tumor size, histological type, grade, clinical stage, recurrence, lymphoid node metastasis and prognosis ( P >0.05) .③The expressive rate of survivin was 53.2% , close relationship was found between the expression of survivin and the recurrence, lymphoid node metastasis . P = 0.025 and 0.015) and shorter survival time. [Conclusion] There is close relationship between p63, survivin and lung carcinomas, especially between the expression of survivin and recurrence, lymphoid node metastasis and prognosis.