白癜风患者血清白介素、肿瘤坏死因子α及粒细胞-巨噬细胞集落刺激因子检测

Serum Level of Interleukin,Tumor Necrosis Factor Alpha and Granulocyte Macrophage-Colony Stimulating Factor in Patients with Vitiligo

目的探讨白介素1β(IL鄄1β)、白介素6(IL鄄6)、白介素8(IL鄄8)、肿瘤坏死因子α(TNF鄄α)及粒细胞-巨噬细胞集落刺激因子(GM鄄CSF)等在白癜风患者血清中的变化。方法采用放射免疫分析法测定50例白癜风患者血清细胞因子水平,并用20例正常人作对照。结果局限性、泛发性白癜风患者血清IL鄄6、GM鄄CSF水平及泛发性患者血清IL鄄1β水平均显著高于对照组。节段型患者血清细胞因子水平与对照组比较差异无显著性。局限性、泛发性患者血清GM鄄CSF水平及泛发性患者血清IL鄄6水平进展期显著高于稳定期。结论IL鄄6和GM鄄CSF在非节段型白癜风自身免疫机制中可能起一定作用。

Objective To study the possible role of cytokines interleukin-1beta(IL-1β),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor alpha(TNF-α)and granulocyte macrophage colony stimulating factor(GM-CSF)in the pathogenesis of vitiligo.Methods The serum levels of IL-β,IL-6,IL-8,TNF-α,and GM-CSF were measured in50patients with vitiligo and20healthy volunteers with radioimmunoassay.Results The serum level of IL-6and GM-CSF in focal type and generalized type of vitiligo,and the serum level of IL-1βin generalized type were significantly higher than those in normal controls.In segmental type of vitiligo,the serum levels of all the cytokines tested were not significantly different from those in normal controls.The GM-CSF levels in focal type and generalized type,and the IL-6level in generalized type of the progressive stage were significantly higher than those in the stable stage.Conclusion IL-6and GM-CSF may be involved in the autoimmune mechanism of non-segmental type of vitiligo.