神经干细胞基因转导治疗帕金森病的研究进展
被引量:2
摘要
随着神经干细胞研究的逐渐成熟,神经干细胞移植是未来治疗帕金森病的主要发展方向。本文就近年来神经干细胞的来源、基因转导和移植治疗帕金森病等方面的研究进展予以综述。
出处
《国外医学(老年医学分册)》
2003年第1期18-22,共5页
Foreign Medical Sciences(Geriatrics)
基金
国家自然科学基金项目(30270491)
广东省团队项目基金(粤科技厅200025)
参考文献16
-
1[1]Alvarez-Buylla A,Herrera DG,Wichterle H.The subventricular zone:soure of neuronal precursors for brain repair.Prog Brain Res,2000;127:1~11
-
2[2]Woodbury D,Schwarz EJ,Prockop DJ et al. Adult rat and human bone marrow stromal cells differentiate into neurons.J Neuroscience Res,2000;61:364~370
-
3[3]Bjornson CR,Rietze RL,Reynolds BA et al. Turning brain into blood:a hematopoietic fate adopted by adult neural stem cells in vivo.Science,1999;283:534~537
-
4[4]Sanchez-Ramos J,Song S,Cardozo-Pelaez F et al. Adult bone marrow stromal cells differentiate into neursl cells in vitro.Exp Neuro,2000;164:247~256
-
5[5]Azizi SA,Stokes D,Augelli BJ et al. Engratment and migration of human bone marrow stromal cells implanted in the brains of albino rats-similarities to astrocyte grafts.Proc Natl Acad Sci U S A,1998;95:3908~3913
-
6[6]Kopen GC,Prockop DJ,Phinney DG.Marrow stromal cells migrate throughout forebrain and cerebellum,and they differrentiate into astrocytes after injection into neonatal mouse brains.Proc Natl Acad Sci U S A , 1999;96:10711~10716
-
7[7]Bjorklund A,Lindvall O.Cell replacement therapies for central nevous system disorders.Nature Neuroscience,2000;3(6):537~544
-
8[8]Nakao N,Yokote H,Nakai K et al. Promotion of survival and regeneration of nigral dopamine neurons in a rat model of Parkinson's disease after implantation of embryonal carcinoma-derived neurons genetically engineered to produce glial cell line-derived neurotrophic factor.J Neurosurg,2000;92(4):659~670
-
9[9]Raymon HK,Thode S,Gage FH.Application of ex vivo gene therapy in the treatment of Parkinson's Disease.Exp Neurol,1997;144(1):82~91
-
10[10]Nakamura K,Bindokas VP,Kowlessur D et al. Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons.J Biol Chem,2001;276(37):34402~34407
同被引文献30
-
1奚淑芳,陈建宗,田季雨.帕金森病的研究现状与进展[J].黑龙江医学,2004,28(9):672-675. 被引量:4
-
2姚庆和,张华,高国栋.帕金森病小鼠模型行为学检测方法的比较研究[J].中国实验动物学报,2006,14(4):264-270. 被引量:19
-
3[1]Kitada T, Asakawa S, Hattori N, et al . Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism[J]. Nature, 1998,392(6676): 605 ~ 608.
-
4[2]Olanow C W, Tatton W G. Etiology and pathogenesis of Parkinson' s disease[J]. Annu Rev Neurosci,1999,22:123 ~ 144.
-
5[3]Ted M, Dawsonand, Valina L, et al .Rare genetic mutations shed light on the pathogenesis of Parkinson disease[J].J Clin Invest,2003,111:145~ 151.
-
6[4]Solano S M,Miller D W,Augood S J, et al .Expression of alpha - synuclein, parkin, and ubiquitin carboxy- terminal hydrolase L1 mRNA in human brain:genes associated with familial Parkinson' s disease [ J ].Ann Neurol,2000,47(2) :201 ~ 210.
-
7[5]Merad - Boudia M, Nicole A, Santiard - Baron D, et al . Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson' s disease [ J ].Biochem Pharmacol, 1998,56(5) :645 ~ 655.
-
8[7]Schapira A H V, Copper J M. Mitochondrial comple I Deficiency in Parkinson' s disease[ J]. J Neurochem, 1990,54: 823.
-
9[8]Shaw P J. Motor neurone disease [ J ]. BMJ,1999,318(7191):1 118~1 121.
-
10[9]Loopuijt L D, Schmidt W J. The role of NMDA receptors in the slow neuronal degeneration of Parkinson' s disease[J]. Amino Acids, 1998,14:17 ~ 23.
二级引证文献7
-
1崔京兰,马英吉,张玉龙,崔胜云.谷胱甘肽与叔丁基邻二苯酚的相互作用及其分析测定研究[J].延边大学学报(自然科学版),2010,36(4):340-344.
-
2谢利霞,赵飞宇,李晖,刘宏乐.左旋多巴与丹参注射液联合用药对鱼藤酮诱导的分化PC12细胞凋亡的保护作用[J].今日药学,2013,23(7):404-409. 被引量:4
-
3王彦春,何方,马骏,周丹,梁艳,龚元勋.电针对帕金森病模型大鼠泛素-蛋白酶体系统的影响[J].中国针灸,2013,33(8):725-729. 被引量:15
-
4邓苙,邬继兰,戴萍,李劲涛.树鼩帕金森病(PD)模型的建立及对其的行为学和形态学研究[J].神经解剖学杂志,2017,33(3):341-344. 被引量:3
-
5张志成,袁圆,王璇,宋庆凯,代解杰.帕金森疾病动物模型的研究进展[J].中国比较医学杂志,2018,28(5):21-27. 被引量:5
-
6王文广,匡德宣,仝品芬,李娜,陆彩霞,罕园园,孙晓梅,代解杰.树鼩的标准化研究与应用进展[J].实验动物科学,2020,37(1):74-78. 被引量:2
-
7李波,角建林,罗婷,冯所芹,孙怀昌.皮下和肌内注射MPTP诱导树鼩帕金森病模型的比较研究[J].云南农业大学学报(自然科学版),2024,39(4):45-53.
-
1王坚,蒋雨平.慢病毒载体介导的基因转导治疗帕金森病[J].中国临床神经科学,2004,12(1):104-107. 被引量:4
-
2刘俊德.基因转导与精神科治疗[J].国外医学(精神病学分册),2000,27(3):174-177.
-
3赵连旭,张杰,孟玲,曹丰,王冬梅,南雪,李艳华,王韫芳,徐小虎,裴雪涛.脑源性神经营养因子基因转导对骨髓间充质干细胞向神经细胞分化的影响[J].中华医学杂志,2004,84(24):2115-2117.
-
4刘福云,胡廷泽.基因治疗在神经干细胞研究中的应用[J].临床小儿外科杂志,2002,1(5):352-356. 被引量:1
-
5何凡,何志义,李蕾,秦雪,邓淑敏,刘芳,阮杏林,冯程程.稳定表达Bcl-2的骨髓间充质干细胞载体的建立及对缺血性损伤保护作用的实验研究[J].中国医科大学学报,2010,39(8):599-602.
-
6Lifen Ren(Department of Physiology, Medical College of Wisconsin, Milwaukee, Wi, USA).GENE THERAPY[J].中国实验血液学杂志,1994,2(1):17-24. 被引量:1
-
7李秀芹,赵亚朴,赵荣山.神经干细胞研究及其移植应用前景[J].华北国防医药,2004,16(3):162-164.
-
8樊东升,康德,GaryJ.Kurtzman,小泽敬也.腺伴随病毒载体介导纹状体神经细胞基因转导的研究[J].中华内科杂志,1998,37(6):382-383.
-
9吴云成,赵永波.帕金森病的干细胞移植及其基因治疗研究进展[J].神经疾病与精神卫生,2004,4(1):59-61. 被引量:1
-
10刘宁,李小怡,王彬冲,朱丽.脑损伤时神经干细胞的修复与神经干细胞移植的研究进展[J].医师进修杂志(外科版),2005,28(9):53-55.