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核因子κB与冠心病的研究进展 被引量：5

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摘要 核因子κB是免疫、炎症和应激反应的主要调控因子,参与动脉粥样硬化和急性冠脉综合征等冠心病的病理过程,抑制NFκB的活化为冠心病的防治提供新的思路。
作者 罗瑛
机构地区 中南大学湘雅医院老年病
出处 《国外医学（老年医学分册）》 2003年第1期25-28,共4页 Foreign Medical Sciences(Geriatrics)
关键词 核因子ΚB 冠心病 研究进展 动脉粥样硬化 药物治疗
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献15

  • 1[1]May MJ,Ghosh S. Singnal transduction through NF-κB.Immunol Today,1998;19:80～88
  • 2[2]Cominacine L,Garbin U,Pasini AF et al.The expression of adhesion molecules on endothelial cells is inhibited by troglitazone through its antioxidant activity.Cell Adhes Commun,1999;7:223～231
  • 3[3]Peng Q,Wei Z,Lau BH.Pycnogenol inhibits tumer necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expresson in human vascular endothelial cells.Cell Mol Life Sci,2000;57:834～842
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同被引文献42

  • 1周同,王锋,孙桂芝,张玉梅,张明均,张冬青,陈楠.抗P-选择素功能域单抗对急性肾损伤防治及免疫防御功能的影响[J].上海第二医科大学学报,2004,24(7):518-523. 被引量：9
  • 2廖爱能,陈爱萍,钟鸿斌,金哲,王小华.氯沙坦对糖尿病肾病细胞间粘附分子-1的影响[J].实用全科医学,2007,5(2):124-125. 被引量：4
  • 3Sassy-Prigent C, Heudes D, Mandet C, et al. Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats [ J ]. Diabetes, 2000,49 ( 4 ) : 466475.
  • 4Kato S, Luyckx VA, Ots M, et al. Renin-angiotensin blockade lowers MC P-1 expression in diabetic rats [ J ]. Kidney Int, 1999,56 ( 10 ) : 1037-1048.
  • 5Chow F, Ozols E, Nikolic-Paterson DJ, et al. Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury[ J ]. Kidney Int ,2004,65 ( 1 ) : 116-128.
  • 6Lee FT, Cao Z, Long DM, et al. Interaction between angiotensin and NF-kappa B-dependent pathways in modulating macrophage infiltration in experimental diabetic nephmpathy [ J ]. J Am Soc Nephrol,2004,15 (12) :2139-2151.
  • 7Park CW, Km JH, Lee JW, et al. High glucose induced intercellular adhesion molecule-1 ( ICAM-1 ) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent [ J ]. Diabetologia, 2000,43(12) :1544-1553.
  • 8Hennann H, Gian CV, Albert M, etal. Preventing micoalbuminuria in patients with diabetes : rationale and design of the Randomised Olmesartan and Diabetes Mieroalbuminuria Prevention (ROADMAP) study [J]. J nypertens,2006,24(4) :403-408.
  • 9Peng Q,Wei Z,Lau BH.Pycnogenol inhibits tumer necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells[J].Cell Mol Life Sci,2000,57(5):834-841.
  • 10Mitani H,Bandoh T,Kimura M, et al.Increased activity of vascular ACE related to atherosclerotic lesions in hyperlipidemic rabbit[J].Am J Physiol,1996,271(3pt2):1065-1071.

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国外医学（老年医学分册）
2003年 第1期

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