血清白细胞介素-8与毒性弥漫性甲状腺肿关系的初步探讨

Preliminary study on the change of serum IL-8 level and its clinical significance on Graves disease

目的 探讨血清白细胞介素 8(IL 8)与毒性弥漫性甲状腺肿 (Graves病 )的相关性。方法 采用ELISA法分别检测了 10 8例Graves病患者和 3 8例正常人的血清IL 8、TRAb水平。结果 Graves病患者血清IL 8水平升高 ,随病情控制 ,IL 8降低 ;血清IL 8水平与TRAb水平呈正相关。结论 IL 8可能与Graves病发病有关 ,且血清IL 8水平的动态变化对判断Graves病的转归。

Objectives To investigate the relationship between serum IL 8 level and Graves disease.Methods Serum IL 8 and TRAb levels were detected by ELASA in 108 patients with Graves disease and 38 controls. Results IL 8 level was increased in patients with Graves disease. But with the remission of the disease, IL 8 level was decreased. Serum IL 8 correlated positively with TRAb level. Conclusions IL 8 might play a role in the development of Graves disease. Detecting IL 8 level is of value to predicting the prognosis and determining the discontinuauce of therapy in Graves disease.