呼吸道合胞病毒对支气管哮喘的诱发作用

The Relationship between Respiratory Syncytial Virus and Bronchial Asthma Attack

目的:探讨RSV与哮喘发病的可能关系。方法:应用间接酶联免疫吸附试验(ELISA)对44例哮喘患者的血清进行RSV特异性IgG抗体检测。结果:44例哮喘患者,RSV感染20例,占45％,其中发热5/13例为RSV感染,哮喘反复发作2/9例为RSV感染,1例半年内发作2次,两次住院均为RSV感染,另1例1年之内发作3次,两次为RSV感染。春夏季节发病RSV阳性4/17例,秋冬季节发病RSV阳性16/27例(x^2=5.34,P<0.05)。结论:哮喘的发作或加重与RSV感染密切相关,其发病机制与病毒感染损伤呼吸道粘膜、机体免疫功能低下有关。

Objective:To study the relationship between the respiratory syncytial virus(RSV) infection and bronchial asthma, attack. Methods: The specific IgG antibodies were tested in sera of 44 cases of bronchial asthma with indirect ELISA. Results: Among the 44 cases,20 (45% ) were infected by RSV,5 from 13 febrile cases were infected by RSV,2 from 9 cases subjected recurrently to asthma attack were infected by RSV, too. Among the 2 cases 1 was hospitalized 2 times within half a year because of asthma attack, and another was attacked by asthma 3 times within a year.They were all infected by RSV.4/17 cases showed evidence of positive reaction to RSV in spring and summer, and 16/27 cases were positive to RSV in autumn and winter (X2 = 5.34, P < 0.05) . Conclusion: There is a close relationship between the asthma attack and RSV infection. The asthma mechanism is concerned with virus infection and injury to the lower respiratory tracts and reduction of immune function of the body. regulating function.