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1型糖尿病的免疫干预 被引量：3

Immuno-Regulation of Type 1 Diabetes Mellitus
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作者 陈蔚
机构地区 复旦大学附属华山医院内分泌科
出处 《复旦学报（医学版）》 CAS CSCD 北大核心 2003年第1期90-92,共3页 Fudan University Journal of Medical Sciences
基金 上海市卫生局中医药科研基金资助项目 ( 982 0 2 9)
关键词 慢性自身免疫性疾病 治疗 1型糖尿病 免疫干预
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献35

  • 1Rabinovitch A,Lee B.Immunoregulatory and cytokine imbalance in the pathogenesis of IDDM.Diabetes,1994,43:613
  • 2李玉秀,王姮,孙琦,杨国华.口服胰岛素、谷氨酸脱羧酶对NOD小鼠糖尿病发生率的影响[J].中华内分泌代谢杂志,2000,16(4):243-245. 被引量：5
  • 3Ploix C,Krenning EP,Hennenmann G,et al.Protection against autoimmune diabetes with oral insulin is associated with the presence of IL-4 type2 T-cell in the pancreas and pancreatic lymph nodes.Diabetes,1998,47:39
  • 4刘芳,俞茂华,朱秋毓,周俊淇,杨秀芳,钟慈声,朱禧星.谷氨酸脱羧酶通过调节T细胞亚群预防NOD小鼠发生1型糖尿病[J].中华内分泌代谢杂志,2000,16(5):306-309. 被引量：5
  • 5杨竹林,周智广,伍汉文,廖二元,杨文.GAD预防NOD鼠胰岛炎和糖尿病的机理研究——胰岛细胞Bcl-2、PCNA表达及意义[J].中国糖尿病杂志,1999,7(2):91-93. 被引量：1
  • 6Maron R,Bakker O,Kiersinga WH,et al.Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes.J Autoimmun,1999,12(4):251
  • 7Ogino T,Kapoan MH,Mosmann TR,et al.Importance of GAD65 peptides and I-A97 in the development of insulitis in nonobese diabetic mice.Immunogenetics,2000,51:538
  • 8Fanciso J,Quintana P,Boros DI,et al.Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in NOD mice:modulation of spontaneous 60-kDa heat shock protein autoimmunity.J Immunol,2000,165(11):6148
  • 9Sai P,Mathew RC,Ragheb S,et al.Prevention of diabetes in the nonobese diabetic mouse by oral immunological treatments.Compa-rative efficency of human insulin and two bacterial antigens,lipopolysacharide from Escherichia coli and glycoprotein extract from klebsiella pneumonia.Diabetes Metab,1996,22:341
  • 10Matsuzaki T,Flores PO,Zheng XX,et al.Prevention of onset in an insulin -dependent diabetes mellitus model,NOD mice,by oral feeding of Lactobacillus casei.APMIS,1997,105:643

二级参考文献16

共引文献69

同被引文献32

  • 1宋旸,常颖,张桂珍.1型糖尿病自身免疫损害机制研究进展[J].长春中医药大学学报,2007,23(3):80-81. 被引量：1
  • 2John AT,Linda SW.Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models[J].Immunity,2001,15(3):387-395.
  • 3Liu J, Beller DI. Distinct pathways for NF-kappa B regulation are associated with aberrant macrophage IL-12 production in lupus- and diabetes-prone mouse strains. J Immunol, 2003,170:4489-4496.
  • 4Hill NJ, Van Gunst K, Sarvetnick N. Th1 and Th2 pancreatic inflammation differentially affects homing of islet- reactive CD4 cells in nonobese diabetic mice. J Immunol, 2003,170:1649-1658.
  • 5Zhang YC, Pileggi A, Agarwal A, et al, Adeno-associated virusmediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes, 2003,52:708-716.
  • 6Rajagopalan G, Kudva YC, Flavell RA, et al. Accelerated diabetes in rat insulin promoter-tumor necrosis factor-alpha transgenic nonobese diabetic mice lacking major histocompatibility class Ⅱ molecules.Diabetes, 2003,52:342-347.
  • 7Zhou W, Zhang F, Aune TM. Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells. J Immunol,2003,170:735-740.
  • 8Koarada S, Wu Y, Olshansky G, et al. Increased nonobese diabetic Th1:Th2 ( IFN-gamma: IL-4) ratio is CD4 + T cell intrinsic and independent of APC genetic background. J Immunol, 2002,169:6580-6587.
  • 9Sparre T, Christensen UB, Mose Larsen P, et al. IL-1beta induced protein changes in diabetes prone BB rat islets of Langerhans identified by proteome analysis. Diabetologia, 2002 ;45:1550-1561.
  • 10Ventura-Oliveira D, Vilella CA, Zanin ME, et al. Kinetics of TNFalpha and IFN-gamma mRNA expression in islets and spleen of NOD mice. Braz J Med Biol Res, 2002,35:1347-1355.

引证文献3

二级引证文献21

复旦学报（医学版）
2003年 第1期

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