苯那普利对老年高血压病患者血管内皮功能的影响

Effect of Benazapril to vascular endothelial function in elderly hypertensive patients

目的 探讨苯那普利对老年高血压血管内皮功能的影响。方法 采用放射免疫法测定 32例老年高血压患者服用苯那普利前后血管内皮功能的影响变化。结果 治疗前 ET水平升高 ,NO水平降低 ,与对照相比有显著性差异 (P<0 .0 1 )。治疗后 ET水平降低 ,NO水平升高 ,治疗前后比较有显著的差异性。结论 苯那普利可降低 ET,升高 NO,从而改善血管内皮功能。

Objective To discuss the effect of Benazapril to vascular endothelial function in elderly hypertensive patients.Methods To determine the changes of endothelin and nitric oxide before and after treated with Benazapril in 32 case elderly hypertensive patients.Results ET level is higher and NO level is lower than control group before treatment (P<0.01); ET level is decreased and NO level is increased after treatment, endothelial function is improved.