托吡酯添加治疗难治性癫癎的临床观察

A clinical study of topiramate as an add-on therapy for patients with refractory epilepsy

目的 观察添加托吡酯对难治性癫的临床效果与副作用。方法 对 18例难治性癫患者 ,加用TPM后观察其发作频率并与加用前进行比较 ,计算总有效率。同时进行临床疗效和副作用观察。结果 病人加用托吡酯后总有效率为 5 0 % ,其中显效率达 2 2 2 % (3例未再发作 )。副反应以胃肠道反应及神经系统症状为主 ,发生率为 5 2 6%。结论 加用TPM治疗难治性癫安全有效。

Objective To assess the efficacy and side effects of topiramate (TPM) as an add-on therapy in patients with refractory epilepsy. Methods The efficacy and side effects of TPM were tested in 18 patients with refractory epilepsy. The efficacy was assessed by comparing the average frequency per month after TPM added up to maintenance period to the baseline therapy.The efficacy and side effects of topiramate were observed at baseline and after treatment with TPM. Results Seizure frequency reduction by ≥50% was found in 50% of patients and 3 patients became seizure-free.Moderate adverse effects was found in 52 6% of patients. Including anorexia and events related to the central nevous system. Conclusions Add-on therapy with TPM is an effective and safe treatment for the patients with refractory epilepsy.