草苁蓉提取物对肝脏癌前病变大鼠血清肿瘤坏死因子含量的影响

Effects of Boschniakia rossica extract for content of tumor necrosis factor in hepatic precancerous lesions of rats

[目的 ]探讨草苁蓉经甲醇提取后进一步分离的水层成分对二乙基亚硝胺所致肝脏癌前病变大鼠血清肿瘤坏死因子含量的影响 .[方法 ]按Solt Farber氏方法建立大鼠肝脏癌前病变模型 ,用草苁蓉提取物饲养大鼠 6周后处死 ,测定血清中的肿瘤坏死因子含量 .[结果 ]草苁蓉经甲醇提取后进一步分离的水层成分可以提高肝脏癌前病变大鼠血清中的肿瘤坏死因子的含量 .[结论

OBJECTIVETo study the effects of water layer component of Boschniakia rossica(BR) extract with methanol for the content of serum tumor necrosis factor(TNF) in the hepatic precancerous lesions of rats induced by diethylinitrosamine.METHODSIt was made that the model of hepatic precancerous lesions in rats induced by modified Solt-Farber protocol ant the content of serum TNF was measured with ELISA method in the rats administered with BR extract for 6 weeks.RESULTSThe water layer component of BR extract further extracted with methanol could increase the content of serum TNF in the hepatic precancerous lesions of rats.CONCLUSIONThe water layer component of BR extract further extracted with methanol has the function of regulating immunization.