摘要
目的 观察泌乳素 (prolactin,PRL)释放抑制剂——溴隐亭 (bromocriptine,BRC)阻断 PRL对大鼠实验性自身免疫性葡萄膜视网膜炎 (experimental autoimmune uveoretinitis,EAU)的治疗效果。 方法 2 4只 Wistar大鼠用牛视网膜可溶性抗原免疫后 ,随机数字表法随机分为治疗组和对照组。治疗组每日给予 BRC葡萄糖溶液 5 mg/(kg· d)经口灌服 ,对照组每日葡萄糖溶液 5 0 g/L经口灌服 ,观察 2组EAU发病情况。免疫 15 d后评价大鼠迟发型变态反应 (delayed type hypersensitivity,DTH) ;免疫 2 3d后眼球摘除 ,行组织学检查。结果 治疗组 EAU发病率和组织学炎症评分均低于对照组 ,其差异均有显著性的意义 (P<0 .0 5 ,P<0 .0 0 1) ;2组之间 DTH比较差异无显著性的意义 (P>0 .0 5 )。结论 在整体水平上 ,BRC干预能够抑制大鼠 EAU的发生和减轻 EAU的病情。
Objective To investigate the effect of bromocriptine on rats with experimental autoimmune uveoretinitis. Methods Tweenty four Wistar rats were immunized by bovine soluble antigen and randomly divided into treatment and control group. The rats in treatment group took bromocriptine orally with the dosage of 5 mg/(kg·d), which could inhibit prolactin (PRL) deliverance, while the rats in control group took glucose solution orally with the dosage of 50 g/(L·d). The clinical changes of all the rats and the delayed type hypersensitivity (DTH) response were detected. The rats were anesthetized and killed after immunized for 21 days, and the eyes were removed and examined histologically. Results The occurrence of EAU and histology scores of rats in treatment group were lower than the controls ( P <0.05, P <0.001). The DTH response of two groups had no statistic difference ( P >0.05). Conclusions Bromocriptine can generally inhibit PRL deliverance, and may also inhibit the occurrence of EAU in rats through neuroendocrine immune regulating network.
出处
《中华眼底病杂志》
CAS
CSCD
2003年第1期34-37,共4页
Chinese Journal of Ocular Fundus Diseases
基金
辽宁省自然科学基金资助项目 (9680 2 0 0 5)
