山莨菪碱预防重型颅脑损伤后呼吸功能不全的临床观察

Effects of anisodamine on espiratory dysfunction caused by head injury

探讨山莨菪碱预防重型颅脑损伤后呼吸功能不全的预防作用。方法 按预先设计的标准选取78例GCS评分小于 8分的重型颅脑损伤患者 ,随机分成预防组和对照组 ,预防组在入院后或手术后即开始接受静脉内注射山莨菪碱 0 .8～ 1.2mg/kg ,稀释至 2 5 0ml,2 4小时持续给药。连续使用 7～ 10天 ,对照组不用此药。每天监测肺通气、氧合功能以及颅内压、心血管功能变化。结果 预防组病例的肺通气、氧合功能基本维持在正常水平 ,对照组病例有明显下降 ,两组病例颅内压、心血管功能变化无明显差异。结论 山莨菪碱预防重型颅脑损伤后呼吸不全疗效显著。

Objective To study prevent effects anisodamine on respiratory disfunction caused by severe head injury.?Methods According to the standards,78 patients (GCS scale<8) were distributed randomly into the prevention group and the contral group. Anisodamine with the dosage 0.8～1.2 mg/kg,diluted to 250ml are continually vein administered in the patients of the prevention group after hospitalization and operation for 7～10d;?while the contral group aren't treated with such drug. Lung ventilation,oxygenation ,intracranial pressure and function of cardiac vascular were monitored every day.?Result Lung ventilation and oxygenation function in the patients of prevention group maintained normal,while that of the contral group decreased signficantly. The intracranial pressure and cardiac vascular function of the both groups showed no signficantly differences.?Conclusion Anisodamine prevent signficantly the respiratory disfunction caused by severe head injury.