甘草总黄酮对大鼠局灶性脑缺血再灌注损害的脑保护作用

Protective effect of flavononids from glycyrrhiza (FG)on focal cerebral ischemia reperfusion

目的 研究甘草总黄酮对大鼠局灶性脑缺血再灌注损害的脑保护作用。方法 我们拟采用线栓法建立的大鼠大脑中动脉 (MCA)缺血再灌注模型 ,并用 3种不同剂量的甘草总黄酮灌服后 ,测定缺血 2h再灌注 2 4h时血清和脑组织中丙二醛 (MDA)、超氧化物歧化酶 (SOD)、一氧化氮 (NO)、一氧化氮合酶 (NOS)活性。结果 发现甘草总黄酮能促进大鼠MCA、缺血再灌注 2 4h后神经功能恢复 ,甘草总黄酮能明显降低血清、脑组织中的MDA、NO含量 ,提高体内SOD的活性。

Objective The animal model of the right MCA ischemia reperfusion was established by suture Methods The treatment groups were given three different dose FG before cerebral ischemia, We observed the changes of malonaldehyde (MDA)?superoxide dismutase(SOD)?nitric oxide(NO)nitric oxide synthase(NOS)in serum and brain after cerebral ishemia 2h reperfusion 24h.Results FG could lower the level of MDA? NO in serum and brain ,improve the activity of SOD.Conclusions FG has protective effect on focal cerebral ischemia reperfusion in rats,and its treatment mechanism maybe come from its effectively scavenging free radicals.