石菖蒲水煎剂抗癫痫动物模型的药效学研究

The Antiepileptic Pharmacological Study of Acorus Tatrinowii Schott on Animal Models

目的 :研究石菖蒲水溶性部分的抗癫痫作用。方法 :采用传统水煎法得到石菖蒲水煎剂 ,分别试验戊四唑 (PTZ)、最大电休克 (MES)急性惊厥模型及PTZ慢性点燃模型。结果 :石菖蒲水煎剂 10 g/kg可显著降低PTZ和MES急性模型的惊厥发作率 (P <0 .0 1) ,与VPA比较无显著性差异 ,并降低PTZ慢性点燃大鼠的发作级别 (P <0 0 1)。结论 :石菖蒲水溶性部分 (即水煎剂 )

Objective:To study the antiepileptic effect of decoction of Acorus tatrinowii Schott. Method: The decoction was made by traditional decoction,and was tested in PTZ,MES acute seizue model in mice and PTZ kindling model in rats. Results: The Decoction 10 g/kg obviously reduced the convulsive rates in PTZ and MES acute model. There was no obvious difference between Decoction and VPA. Decoction could reduced the seizure level of PTZ kindling rats. Conclusion: The decoction of Acorus tatrinowii Schott had prominent antiepileptic effect.